Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.

Microvesicular caspase-1 mediates lymphocyte apoptosis in sepsis.

OBJECTIVE:Immune dysregulation during sepsis is poorly understood, however, lymphocyte apoptosis has been shown to correlate with poor outcomes in septic patients. The inflammasome, a molecular complex which includes caspase-1, is essential to the innate immune response to infection and also importa...

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Bibliographic Details
Main Authors: Matthew C Exline, Steven Justiniano, Jennifer L Hollyfield, Freweine Berhe, Beth Y Besecker, Srabani Das, Mark D Wewers, Anasuya Sarkar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3958341?pdf=render

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