Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte developmental competence. Our proof-of-concept experiments show that replacement of...

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Bibliographic Details
Main Authors:	Nuno Costa-Borges, Katharina Spath, Irene Miguel-Escalada, Enric Mestres, Rosa Balmaseda, Anna Serafín, Maria Garcia-Jiménez, Ivette Vanrell, Jesús González, Klaus Rink, Dagan Wells, Gloria Calderón
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2020-04-01
Series:	eLife
Subjects:	Infertility Spindle transfer oocytes mitochondrial DNA heteroplasmy embryo development
Online Access:	https://elifesciences.org/articles/48591

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