Body mass index and severity of parkinsonism in multiple system atrophy
Patients with neurodegenerative disorders lose body weight as their diseases progress. In Parkinson’s disease (PD), however, autonomic dysfunction is associated with increased body mass index (BMI). We investigated the correlation between BMI, clinical features, and autonomic dysfunction in patients...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-09-01
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| Series: | Neurology International |
| Subjects: | |
| Online Access: | http://www.pagepress.org/journals/index.php/ni/article/view/7276 |
| _version_ | 1797936865176715264 |
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| author | Ai Suzuki Hitoshi Mochizuki Yuka Ebihara Kazutaka Shiomi Masamitsu Nakazato |
| author_facet | Ai Suzuki Hitoshi Mochizuki Yuka Ebihara Kazutaka Shiomi Masamitsu Nakazato |
| author_sort | Ai Suzuki |
| collection | DOAJ |
| description | Patients with neurodegenerative disorders lose body weight as their diseases progress. In Parkinson’s disease (PD), however, autonomic dysfunction is associated with increased body mass index (BMI). We investigated the correlation between BMI, clinical features, and autonomic dysfunction in patients with multiple system atrophy with predominant parkinsonism (MSAP). BMI, clinical features, cardiac 123Imetaiodobenzylguanidine scintigraphy (MIBG), Hoehn and Yahr (H-Y) stage, and the coefficient of variation of the R-R interval (CVRR) were analyzed in 50 patients with MSA-P. BMI showed no significant correlation with MIBG parameters or CVRR. On the other hand, the H-Y stage was significantly negatively correlated with BMI. Higher H-Y stage indicates a more severe neuromuscular state in MSA-P and is considered to be related to higher energy expenditure and decrease of BMI. Patients with MSA-P lose weight as the disease progresses. This is the first report indicating a significant correlation between disease severity and BMI decrease in MSA. |
| first_indexed | 2024-04-10T18:35:53Z |
| format | Article |
| id | doaj.art-f843d816057341b9a502147d16c9ced3 |
| institution | Directory Open Access Journal |
| issn | 2035-8385 2035-8377 |
| language | English |
| last_indexed | 2024-04-10T18:35:53Z |
| publishDate | 2017-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-f843d816057341b9a502147d16c9ced32023-02-02T01:44:03ZengMDPI AGNeurology International2035-83852035-83772017-09-019310.4081/ni.2017.72763786Body mass index and severity of parkinsonism in multiple system atrophyAi Suzuki0Hitoshi Mochizuki1Yuka Ebihara2Kazutaka Shiomi3Masamitsu Nakazato4Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, MiyazakiDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, MiyazakiDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, MiyazakiDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, MiyazakiDivision of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, MiyazakiPatients with neurodegenerative disorders lose body weight as their diseases progress. In Parkinson’s disease (PD), however, autonomic dysfunction is associated with increased body mass index (BMI). We investigated the correlation between BMI, clinical features, and autonomic dysfunction in patients with multiple system atrophy with predominant parkinsonism (MSAP). BMI, clinical features, cardiac 123Imetaiodobenzylguanidine scintigraphy (MIBG), Hoehn and Yahr (H-Y) stage, and the coefficient of variation of the R-R interval (CVRR) were analyzed in 50 patients with MSA-P. BMI showed no significant correlation with MIBG parameters or CVRR. On the other hand, the H-Y stage was significantly negatively correlated with BMI. Higher H-Y stage indicates a more severe neuromuscular state in MSA-P and is considered to be related to higher energy expenditure and decrease of BMI. Patients with MSA-P lose weight as the disease progresses. This is the first report indicating a significant correlation between disease severity and BMI decrease in MSA.http://www.pagepress.org/journals/index.php/ni/article/view/7276Multiple system atrophyBody mass indexCardiac 123I-metaiodobenzylguanidine scintigraphyCoefficient of variation of the R-R interval |
| spellingShingle | Ai Suzuki Hitoshi Mochizuki Yuka Ebihara Kazutaka Shiomi Masamitsu Nakazato Body mass index and severity of parkinsonism in multiple system atrophy Neurology International Multiple system atrophy Body mass index Cardiac 123I-metaiodobenzylguanidine scintigraphy Coefficient of variation of the R-R interval |
| title | Body mass index and severity of parkinsonism in multiple system atrophy |
| title_full | Body mass index and severity of parkinsonism in multiple system atrophy |
| title_fullStr | Body mass index and severity of parkinsonism in multiple system atrophy |
| title_full_unstemmed | Body mass index and severity of parkinsonism in multiple system atrophy |
| title_short | Body mass index and severity of parkinsonism in multiple system atrophy |
| title_sort | body mass index and severity of parkinsonism in multiple system atrophy |
| topic | Multiple system atrophy Body mass index Cardiac 123I-metaiodobenzylguanidine scintigraphy Coefficient of variation of the R-R interval |
| url | http://www.pagepress.org/journals/index.php/ni/article/view/7276 |
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