The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research
Aging is a major risk factor for the leading causes of mortality, and the incidence of age-related diseases including cardiovascular disease, kidney disease and metabolic disease increases with age. NAD<sup>+</sup> is a classic coenzyme that exists in all species, and that plays a crucia...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/4/595 |
| _version_ | 1797621826170388480 |
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| author | Munehiro Kitada Shin-ichi Araki Daisuke Koya |
| author_facet | Munehiro Kitada Shin-ichi Araki Daisuke Koya |
| author_sort | Munehiro Kitada |
| collection | DOAJ |
| description | Aging is a major risk factor for the leading causes of mortality, and the incidence of age-related diseases including cardiovascular disease, kidney disease and metabolic disease increases with age. NAD<sup>+</sup> is a classic coenzyme that exists in all species, and that plays a crucial role in oxidation–reduction reactions. It is also involved in the regulation of many cellular functions including inflammation, oxidative stress and differentiation. NAD<sup>+</sup> declines with aging in various organs, and the reduction in NAD<sup>+</sup> is possibly involved in the development of age-related cellular dysfunction in cardiorenal metabolic organs through the accumulation of inflammation and oxidative stress. Levels of NAD<sup>+</sup> are regulated by the balance between its synthesis and degradation. CD38 is the main NAD<sup>+</sup>-degrading enzyme, and CD38 is activated in response to inflammation with aging, which is associated with the reduction in NAD<sup>+</sup> levels. In this review, focusing on CD38, we discuss the role of CD38 in aging and the pathogenesis of age-related diseases, including cardiorenal metabolic disease. |
| first_indexed | 2024-03-11T09:01:29Z |
| format | Article |
| id | doaj.art-f8443d41f3ad4ac8bc99d85a30f653f6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T09:01:29Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f8443d41f3ad4ac8bc99d85a30f653f62023-11-16T19:44:32ZengMDPI AGCells2073-44092023-02-0112459510.3390/cells12040595The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic ResearchMunehiro Kitada0Shin-ichi Araki1Daisuke Koya2Department of Internal Medicine, Hamada Neurosurgery and Internal Medicine Clinic, Wakayama 641-8509, JapanDepartment of Nephrology, Wakayama Medical University, Wakayama 641-8509, JapanOmi Medical Center, Kusatsu, Shiga 525-8585, JapanAging is a major risk factor for the leading causes of mortality, and the incidence of age-related diseases including cardiovascular disease, kidney disease and metabolic disease increases with age. NAD<sup>+</sup> is a classic coenzyme that exists in all species, and that plays a crucial role in oxidation–reduction reactions. It is also involved in the regulation of many cellular functions including inflammation, oxidative stress and differentiation. NAD<sup>+</sup> declines with aging in various organs, and the reduction in NAD<sup>+</sup> is possibly involved in the development of age-related cellular dysfunction in cardiorenal metabolic organs through the accumulation of inflammation and oxidative stress. Levels of NAD<sup>+</sup> are regulated by the balance between its synthesis and degradation. CD38 is the main NAD<sup>+</sup>-degrading enzyme, and CD38 is activated in response to inflammation with aging, which is associated with the reduction in NAD<sup>+</sup> levels. In this review, focusing on CD38, we discuss the role of CD38 in aging and the pathogenesis of age-related diseases, including cardiorenal metabolic disease.https://www.mdpi.com/2073-4409/12/4/595CD38NAD<sup>+</sup>agingcardiovascular diseasekidney diseasemetabolic disease |
| spellingShingle | Munehiro Kitada Shin-ichi Araki Daisuke Koya The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research Cells CD38 NAD<sup>+</sup> aging cardiovascular disease kidney disease metabolic disease |
| title | The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research |
| title_full | The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research |
| title_fullStr | The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research |
| title_full_unstemmed | The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research |
| title_short | The Role of CD38 in the Pathogenesis of Cardiorenal Metabolic Disease and Aging, an Approach from Basic Research |
| title_sort | role of cd38 in the pathogenesis of cardiorenal metabolic disease and aging an approach from basic research |
| topic | CD38 NAD<sup>+</sup> aging cardiovascular disease kidney disease metabolic disease |
| url | https://www.mdpi.com/2073-4409/12/4/595 |
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