Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study
Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after...
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| Format: | Article |
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MDPI AG
2021-07-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/8/8/633 |
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| author | Grzegorz Kowalewski Piotr Kaliciński Marek Stefanowicz Ryszard Grenda Piotr Czubkowski Marek Szymczak |
| author_facet | Grzegorz Kowalewski Piotr Kaliciński Marek Stefanowicz Ryszard Grenda Piotr Czubkowski Marek Szymczak |
| author_sort | Grzegorz Kowalewski |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after liver transplantation remaining under constant care of the Department of Pediatric Surgery and Organ Transplantation. The analysis included several tests: estimated glomerular function (eGFR), results of screening for renal tubular defects and blood concentrations of basic immunosuppressive drug-tacrolimus. CKD was diagnosed in 3% of children at 12 years after LT. The maintaining of tacrolimus concentrations >4 ng/mL in long-term observation was associated with a significant increase of microalbuminuria. The presence of microalbuminuria, regarded as a risk factor of CKD, confirmed the necessity of regular comprehensive assessment of patients in long-term follow-up. |
| first_indexed | 2024-03-10T08:55:05Z |
| format | Article |
| id | doaj.art-f84455709a9d47309ef12ed924d0e4ec |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-10T08:55:05Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-f84455709a9d47309ef12ed924d0e4ec2023-11-22T07:13:41ZengMDPI AGChildren2227-90672021-07-018863310.3390/children8080633Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective StudyGrzegorz Kowalewski0Piotr Kaliciński1Marek Stefanowicz2Ryszard Grenda3Piotr Czubkowski4Marek Szymczak5Department of Pediatric Surgery and Organ Transplantation, Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Nephrology, Kidney Transplantation and Hypertension, Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatric Surgery and Organ Transplantation, Children’s Memorial Health Institute, 04-730 Warsaw, PolandChronic kidney disease (CKD) is a common complication after liver transplantation (LT). Its prevalence with modern immunosuppression regimens, especially in children, is variable depending on the transplantation era. The study included 61 pediatric patients with at least 10 years of follow-up after liver transplantation remaining under constant care of the Department of Pediatric Surgery and Organ Transplantation. The analysis included several tests: estimated glomerular function (eGFR), results of screening for renal tubular defects and blood concentrations of basic immunosuppressive drug-tacrolimus. CKD was diagnosed in 3% of children at 12 years after LT. The maintaining of tacrolimus concentrations >4 ng/mL in long-term observation was associated with a significant increase of microalbuminuria. The presence of microalbuminuria, regarded as a risk factor of CKD, confirmed the necessity of regular comprehensive assessment of patients in long-term follow-up.https://www.mdpi.com/2227-9067/8/8/633liver transplantationchronic kidney diseaseimmunosuppression |
| spellingShingle | Grzegorz Kowalewski Piotr Kaliciński Marek Stefanowicz Ryszard Grenda Piotr Czubkowski Marek Szymczak Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study Children liver transplantation chronic kidney disease immunosuppression |
| title | Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study |
| title_full | Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study |
| title_fullStr | Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study |
| title_full_unstemmed | Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study |
| title_short | Long-Term Follow-Up of Renal Function in Children after Liver Transplantation—A Single Center Retrospective Study |
| title_sort | long term follow up of renal function in children after liver transplantation a single center retrospective study |
| topic | liver transplantation chronic kidney disease immunosuppression |
| url | https://www.mdpi.com/2227-9067/8/8/633 |
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