Echocardiographic assessment of radial right ventricular function in heart transplant recipients
Abstract Aims Right ventricular (RV) allograft dysfunction is present in half of all heart transplant (HT) recipients. Non‐invasive assessment of RV function in the setting of rejection is not well described. We outline an echocardiographic technique, short‐axis fractional area change (SAXFAC), to e...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-12-01
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| Series: | ESC Heart Failure |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ehf2.13651 |
| _version_ | 1818205682225119232 |
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| author | Marc Atzenhoefer Arshad Jahangir Abby Payne Mohamed Hendawi Omar Dakwar Mahmoud Ali Vinay Thohan Lakshmi Muthukumar |
| author_facet | Marc Atzenhoefer Arshad Jahangir Abby Payne Mohamed Hendawi Omar Dakwar Mahmoud Ali Vinay Thohan Lakshmi Muthukumar |
| author_sort | Marc Atzenhoefer |
| collection | DOAJ |
| description | Abstract Aims Right ventricular (RV) allograft dysfunction is present in half of all heart transplant (HT) recipients. Non‐invasive assessment of RV function in the setting of rejection is not well described. We outline an echocardiographic technique, short‐axis fractional area change (SAXFAC), to evaluate RV function in the HT population and correlate this with the grade of pathologic rejection. Methods and results We retrospectively reviewed the electronic medical records of 110 people who received a HT between 1 January 2015 and 29 February 2020 and had no evidence of rejection. One hundred eighty‐two transthoracic echocardiograms (TTEs) completed up to 1 year from the date of transplantation were analysed for the target acoustic window, the parasternal mid‐ventricular short‐axis view. Sixty‐one TTEs from 23 healthy transplants were deemed appropriate for SAXFAC determination. Thirty‐three organ recipients with at least grade 1R allograft rejection were also identified, and their TTEs screened for SAXFAC analysis. Two expert readers independently calculated SAXFAC as follows: RV end‐diastolic area minus end‐systolic area divided by end‐diastolic area. Using commercially available software (Epsilon, Ann Arbor, Michigan), we quantified RV radial strain, longitudinal strain, and apical fractional area change (FAC). Twenty‐eight transplant recipients with grade 0R or 1R rejection and nine patients with clinically significant rejection completed the study analysis. SAXFAC demonstrated significant variability in the entire population with an inverse relationship to severity of allograft rejection (P ≤ 0.01). Radial strain and FAC were also associated with clinically significant rejection (P ≤ 0.01). Conclusions Short‐axis fractional area change is a simple two‐dimensional technique to assess RV function in HT recipients and showed no significant inter‐observer variability. In our small, single‐centre, retrospective case series, lower SAXFAC values were associated with clinically significant allograft rejection. The small sample size and infrequent occurrence of rejection make our observations hypothesis‐generating only. We advocate dedicated RV SAXFAC imaging planes be included when assessing allograft function. |
| first_indexed | 2024-12-12T04:01:01Z |
| format | Article |
| id | doaj.art-f8448c45a129443c924d366f65d281c2 |
| institution | Directory Open Access Journal |
| issn | 2055-5822 |
| language | English |
| last_indexed | 2024-12-12T04:01:01Z |
| publishDate | 2021-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | ESC Heart Failure |
| spelling | doaj.art-f8448c45a129443c924d366f65d281c22022-12-22T00:39:03ZengWileyESC Heart Failure2055-58222021-12-01865613561610.1002/ehf2.13651Echocardiographic assessment of radial right ventricular function in heart transplant recipientsMarc Atzenhoefer0Arshad Jahangir1Abby Payne2Mohamed Hendawi3Omar Dakwar4Mahmoud Ali5Vinay Thohan6Lakshmi Muthukumar7Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers University of Wisconsin School of Medicine and Public Health 2801 W. Kinnickinnic River Parkway, Ste. 880 Milwaukee WI 53215 USAAurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers University of Wisconsin School of Medicine and Public Health 2801 W. Kinnickinnic River Parkway, Ste. 880 Milwaukee WI 53215 USAAurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers University of Wisconsin School of Medicine and Public Health 2801 W. Kinnickinnic River Parkway, Ste. 880 Milwaukee WI 53215 USAAurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers University of Wisconsin School of Medicine and Public Health 2801 W. Kinnickinnic River Parkway, Ste. 880 Milwaukee WI 53215 USAQuality Management Aurora St. Luke's Medical Center Milwaukee WI USAAurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers University of Wisconsin School of Medicine and Public Health 2801 W. Kinnickinnic River Parkway, Ste. 880 Milwaukee WI 53215 USAMission Health System/HCA Asheville NC USAAurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers University of Wisconsin School of Medicine and Public Health 2801 W. Kinnickinnic River Parkway, Ste. 880 Milwaukee WI 53215 USAAbstract Aims Right ventricular (RV) allograft dysfunction is present in half of all heart transplant (HT) recipients. Non‐invasive assessment of RV function in the setting of rejection is not well described. We outline an echocardiographic technique, short‐axis fractional area change (SAXFAC), to evaluate RV function in the HT population and correlate this with the grade of pathologic rejection. Methods and results We retrospectively reviewed the electronic medical records of 110 people who received a HT between 1 January 2015 and 29 February 2020 and had no evidence of rejection. One hundred eighty‐two transthoracic echocardiograms (TTEs) completed up to 1 year from the date of transplantation were analysed for the target acoustic window, the parasternal mid‐ventricular short‐axis view. Sixty‐one TTEs from 23 healthy transplants were deemed appropriate for SAXFAC determination. Thirty‐three organ recipients with at least grade 1R allograft rejection were also identified, and their TTEs screened for SAXFAC analysis. Two expert readers independently calculated SAXFAC as follows: RV end‐diastolic area minus end‐systolic area divided by end‐diastolic area. Using commercially available software (Epsilon, Ann Arbor, Michigan), we quantified RV radial strain, longitudinal strain, and apical fractional area change (FAC). Twenty‐eight transplant recipients with grade 0R or 1R rejection and nine patients with clinically significant rejection completed the study analysis. SAXFAC demonstrated significant variability in the entire population with an inverse relationship to severity of allograft rejection (P ≤ 0.01). Radial strain and FAC were also associated with clinically significant rejection (P ≤ 0.01). Conclusions Short‐axis fractional area change is a simple two‐dimensional technique to assess RV function in HT recipients and showed no significant inter‐observer variability. In our small, single‐centre, retrospective case series, lower SAXFAC values were associated with clinically significant allograft rejection. The small sample size and infrequent occurrence of rejection make our observations hypothesis‐generating only. We advocate dedicated RV SAXFAC imaging planes be included when assessing allograft function.https://doi.org/10.1002/ehf2.13651FunctionHeart transplantNon‐invasiveRejectionRight ventricle |
| spellingShingle | Marc Atzenhoefer Arshad Jahangir Abby Payne Mohamed Hendawi Omar Dakwar Mahmoud Ali Vinay Thohan Lakshmi Muthukumar Echocardiographic assessment of radial right ventricular function in heart transplant recipients ESC Heart Failure Function Heart transplant Non‐invasive Rejection Right ventricle |
| title | Echocardiographic assessment of radial right ventricular function in heart transplant recipients |
| title_full | Echocardiographic assessment of radial right ventricular function in heart transplant recipients |
| title_fullStr | Echocardiographic assessment of radial right ventricular function in heart transplant recipients |
| title_full_unstemmed | Echocardiographic assessment of radial right ventricular function in heart transplant recipients |
| title_short | Echocardiographic assessment of radial right ventricular function in heart transplant recipients |
| title_sort | echocardiographic assessment of radial right ventricular function in heart transplant recipients |
| topic | Function Heart transplant Non‐invasive Rejection Right ventricle |
| url | https://doi.org/10.1002/ehf2.13651 |
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