Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves.

Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves.

Twist1, a basic helix-loop-helix transcription factor, is expressed in mesenchymal precursor populations during embryogenesis and in metastatic cancer cells. In the developing heart, Twist1 is highly expressed in endocardial cushion (ECC) valve mesenchymal cells and is down regulated during valve di...

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Bibliographic Details
Main Authors: Mary P Lee, Katherine E Yutzey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3248441?pdf=render

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