Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.
Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This is a new approach of incorporating, tryptophan and histidine...
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| Format: | Article |
| Language: | English |
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College of Pharmacy / Mustansiriyah University
2022-04-01
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| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/794 |
| _version_ | 1797223968894091264 |
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| author | Yasir F. Muhsin Shakir M. Alwan Ayad Kareem Khan |
| author_facet | Yasir F. Muhsin Shakir M. Alwan Ayad Kareem Khan |
| author_sort | Yasir F. Muhsin |
| collection | DOAJ |
| description |
Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This is a new
approach of incorporating, tryptophan and histidine into the the primary amino group of cephalexin, in order to provide a bulky group very close to the β-lactam ring. This chemical addition act as isosteric group to the alkoximino that protect beta lactam ring from bacterial beta lactamase enzyme. The new derivatives may show resistance to β-lactamases, improve activity and pharmacokinetic properties and may give new life for old drugs that are susceptible to hydrolysis by most β-lactamases. The chemical structures of these derivatives were confirmed by: FTIR, 1H-NMR spectroscopy, elemental micro analysis and some physical properties. Molecular docking on serine beta lactamase and prediction of ADME parameters were recorded using GOLD suite and Swiss ADME software respectively. Docking scores of the new derivatives of Cephalexin on β-lactamases were higher than those of Cephalexin, which may indicate better activity
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| first_indexed | 2024-04-24T13:45:39Z |
| format | Article |
| id | doaj.art-f84a67dfc69349219dbf11c1d823cda0 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:45:39Z |
| publishDate | 2022-04-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f84a67dfc69349219dbf11c1d823cda02024-04-04T06:56:30ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2022-04-0121310.32947/ajps.v21i3.794Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin.Yasir F. Muhsin0Shakir M. Alwan1Ayad Kareem Khan2Department of Pharmacy, Ashur University College, Baghdad-IraqDepartment of Pharmacy, Al-Farabi University College, Baghdad-IraqDepartment of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad-Iraq. Infections caused by bacteria have a significant impact on public health. Chemical synthesis of new derivatives of cephalexin inked to amino acid (tryptophan or histidine) through an amide bond at the acyl side chain is achieved. This is a new approach of incorporating, tryptophan and histidine into the the primary amino group of cephalexin, in order to provide a bulky group very close to the β-lactam ring. This chemical addition act as isosteric group to the alkoximino that protect beta lactam ring from bacterial beta lactamase enzyme. The new derivatives may show resistance to β-lactamases, improve activity and pharmacokinetic properties and may give new life for old drugs that are susceptible to hydrolysis by most β-lactamases. The chemical structures of these derivatives were confirmed by: FTIR, 1H-NMR spectroscopy, elemental micro analysis and some physical properties. Molecular docking on serine beta lactamase and prediction of ADME parameters were recorded using GOLD suite and Swiss ADME software respectively. Docking scores of the new derivatives of Cephalexin on β-lactamases were higher than those of Cephalexin, which may indicate better activity https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/794 |
| spellingShingle | Yasir F. Muhsin Shakir M. Alwan Ayad Kareem Khan Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| title | Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. |
| title_full | Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. |
| title_fullStr | Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. |
| title_full_unstemmed | Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. |
| title_short | Design, Molecular Docking, Synthesis of Aromatic Amino Acids Linked to Cephalexin. |
| title_sort | design molecular docking synthesis of aromatic amino acids linked to cephalexin |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/794 |
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