A unique case of anti-GBM disease with concomitant anti-PLA2R positivity
Abstract Background Concomitant occurrence of anti-GBM disease and anti-PLA2R positive membranous nephropathy have been previously described. However, to the best of our knowledge, this is the first case report that documents the co-occurrence of the diseases proven by both serologic and histologic...
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| Format: | Article |
| Language: | English |
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BMC
2022-10-01
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| Series: | BMC Nephrology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12882-022-02941-1 |
| _version_ | 1797986064588079104 |
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| author | Adél Molnár András Tislér Deján Dobi Ákos Pethő |
| author_facet | Adél Molnár András Tislér Deján Dobi Ákos Pethő |
| author_sort | Adél Molnár |
| collection | DOAJ |
| description | Abstract Background Concomitant occurrence of anti-GBM disease and anti-PLA2R positive membranous nephropathy have been previously described. However, to the best of our knowledge, this is the first case report that documents the co-occurrence of the diseases proven by both serologic and histologic methods. Case presentation A 51-year-old woman presented to hospital with nausea, bilateral lower extremity edema, dyspnea, dark urine, and then anuria. Symptoms developed one month after an upper respiratory tract infection. Laboratory results showed acute kidney injury, and hypoalbuminemia. Immunologic examination revealed both anti-GBM and anti-PLA2R positivity. Kidney biopsy demonstrated the histological features of Goodpasture’s disease and anti-PLA2R positive membranous nephropathy. Steroid, cyclophosphamide, and plasmapheresis were commenced. Despite the combined immunosuppressive, the patient remained on renal replacement therapy. Conclusions Microbial kidney injury can trigger multiple autoimmune diseases. The simultaneous occurrence of anti-glomerular basement (anti-GBM) disease and membranous nephropathy is extremely rare. Delayed recognition leads to delayed treatment, causing worse renal and patient outcomes, as well as increased financial costs. |
| first_indexed | 2024-04-11T07:28:10Z |
| format | Article |
| id | doaj.art-f84c49a4429a4edf8129de76e93b99c3 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-11T07:28:10Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-f84c49a4429a4edf8129de76e93b99c32022-12-22T04:37:01ZengBMCBMC Nephrology1471-23692022-10-012311510.1186/s12882-022-02941-1A unique case of anti-GBM disease with concomitant anti-PLA2R positivityAdél Molnár0András Tislér1Deján Dobi2Ákos Pethő3Department of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis UniversityDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis UniversityInstitute of Pathology, Forensic and Insurance Medicine, Semmelweis UniversityDepartment of Internal Medicine and Oncology, Faculty of Medicine, Semmelweis UniversityAbstract Background Concomitant occurrence of anti-GBM disease and anti-PLA2R positive membranous nephropathy have been previously described. However, to the best of our knowledge, this is the first case report that documents the co-occurrence of the diseases proven by both serologic and histologic methods. Case presentation A 51-year-old woman presented to hospital with nausea, bilateral lower extremity edema, dyspnea, dark urine, and then anuria. Symptoms developed one month after an upper respiratory tract infection. Laboratory results showed acute kidney injury, and hypoalbuminemia. Immunologic examination revealed both anti-GBM and anti-PLA2R positivity. Kidney biopsy demonstrated the histological features of Goodpasture’s disease and anti-PLA2R positive membranous nephropathy. Steroid, cyclophosphamide, and plasmapheresis were commenced. Despite the combined immunosuppressive, the patient remained on renal replacement therapy. Conclusions Microbial kidney injury can trigger multiple autoimmune diseases. The simultaneous occurrence of anti-glomerular basement (anti-GBM) disease and membranous nephropathy is extremely rare. Delayed recognition leads to delayed treatment, causing worse renal and patient outcomes, as well as increased financial costs.https://doi.org/10.1186/s12882-022-02941-1Membranous nephropathyAnti-GBM diseaseGoodpasture’s syndromeGlomerulonephritis |
| spellingShingle | Adél Molnár András Tislér Deján Dobi Ákos Pethő A unique case of anti-GBM disease with concomitant anti-PLA2R positivity BMC Nephrology Membranous nephropathy Anti-GBM disease Goodpasture’s syndrome Glomerulonephritis |
| title | A unique case of anti-GBM disease with concomitant anti-PLA2R positivity |
| title_full | A unique case of anti-GBM disease with concomitant anti-PLA2R positivity |
| title_fullStr | A unique case of anti-GBM disease with concomitant anti-PLA2R positivity |
| title_full_unstemmed | A unique case of anti-GBM disease with concomitant anti-PLA2R positivity |
| title_short | A unique case of anti-GBM disease with concomitant anti-PLA2R positivity |
| title_sort | unique case of anti gbm disease with concomitant anti pla2r positivity |
| topic | Membranous nephropathy Anti-GBM disease Goodpasture’s syndrome Glomerulonephritis |
| url | https://doi.org/10.1186/s12882-022-02941-1 |
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