Chromosome 2p14 is linked to susceptibility to leprosy.
BACKGROUND: A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established. METHODOLOGY: A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3253103?pdf=render |
| _version_ | 1811203660812648448 |
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| author | Qing Yang Hong Liu Hui-Qi Low Haifeng Wang Yongxiang Yu Xi'an Fu Gongqi Yu Mingfei Chen Xiaoxiao Yan Shumin Chen Wei Huang Jianjun Liu Furen Zhang |
| author_facet | Qing Yang Hong Liu Hui-Qi Low Haifeng Wang Yongxiang Yu Xi'an Fu Gongqi Yu Mingfei Chen Xiaoxiao Yan Shumin Chen Wei Huang Jianjun Liu Furen Zhang |
| author_sort | Qing Yang |
| collection | DOAJ |
| description | BACKGROUND: A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established. METHODOLOGY: A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1. PRINCIPAL FINDINGS: Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm of odds (HLOD) score of 3.51 (rs1106577) under a recessive model of inheritance, while suggestive evidence was identified on chr.4q22 (HLOD 2.92, rs1349350, dominant model), chr. 8q24 (HLOD 2.74, rs1618523, recessive model) and chr.16q24 (HLOD 1.93, rs276990 dominant model). Our study also provided moderate evidence for a linkage locus on chromosome 6q24-26 by non-parametric linkage analysis (rs6570858, LOD 1.54, p = 0.004), overlapping a previously reported linkage region on chromosome 6q25-26. CONCLUSION: A genome-wide linkage analysis has identified a new linkage locus on chromosome 2p14 for leprosy in Pedigrees from China. |
| first_indexed | 2024-04-12T02:59:02Z |
| format | Article |
| id | doaj.art-f84c7f3c860444fdae5fea4ae82dc1a2 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T02:59:02Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f84c7f3c860444fdae5fea4ae82dc1a22022-12-22T03:50:44ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0171e2974710.1371/journal.pone.0029747Chromosome 2p14 is linked to susceptibility to leprosy.Qing YangHong LiuHui-Qi LowHaifeng WangYongxiang YuXi'an FuGongqi YuMingfei ChenXiaoxiao YanShumin ChenWei HuangJianjun LiuFuren ZhangBACKGROUND: A genetic component to the etiology of leprosy is well recognized but the mechanism of inheritance and the genes involved are yet to be fully established. METHODOLOGY: A genome-wide single nucleotide polymorphism (SNP) based linkage analysis was carried out using 23 pedigrees, each with 3 to 7 family members affected by leprosy. Multipoint parametric and non-parametric linkage analyses were performed using MERLIN 1.1.1. PRINCIPAL FINDINGS: Genome-wide significant evidence for linkage was identified on chromosome 2p14 with a heterogeneity logarithm of odds (HLOD) score of 3.51 (rs1106577) under a recessive model of inheritance, while suggestive evidence was identified on chr.4q22 (HLOD 2.92, rs1349350, dominant model), chr. 8q24 (HLOD 2.74, rs1618523, recessive model) and chr.16q24 (HLOD 1.93, rs276990 dominant model). Our study also provided moderate evidence for a linkage locus on chromosome 6q24-26 by non-parametric linkage analysis (rs6570858, LOD 1.54, p = 0.004), overlapping a previously reported linkage region on chromosome 6q25-26. CONCLUSION: A genome-wide linkage analysis has identified a new linkage locus on chromosome 2p14 for leprosy in Pedigrees from China.http://europepmc.org/articles/PMC3253103?pdf=render |
| spellingShingle | Qing Yang Hong Liu Hui-Qi Low Haifeng Wang Yongxiang Yu Xi'an Fu Gongqi Yu Mingfei Chen Xiaoxiao Yan Shumin Chen Wei Huang Jianjun Liu Furen Zhang Chromosome 2p14 is linked to susceptibility to leprosy. PLoS ONE |
| title | Chromosome 2p14 is linked to susceptibility to leprosy. |
| title_full | Chromosome 2p14 is linked to susceptibility to leprosy. |
| title_fullStr | Chromosome 2p14 is linked to susceptibility to leprosy. |
| title_full_unstemmed | Chromosome 2p14 is linked to susceptibility to leprosy. |
| title_short | Chromosome 2p14 is linked to susceptibility to leprosy. |
| title_sort | chromosome 2p14 is linked to susceptibility to leprosy |
| url | http://europepmc.org/articles/PMC3253103?pdf=render |
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