Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis
Abstract Background The relationship between anti-estrogen drugs and macular telangiectasia type 2 (MacTel-2) remains unknown. Here we report a case with anti-estrogen maculopathy resembling MacTel-2 with improved visual function and macular morphology following cessation of anti-estrogen drugs. Cas...
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| Format: | Article |
| Language: | English |
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BMC
2019-12-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-019-1280-1 |
| _version_ | 1818428789715107840 |
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| author | Akihiro Shinkai Wataru Saito Yuki Hashimoto Susumu Ishida |
| author_facet | Akihiro Shinkai Wataru Saito Yuki Hashimoto Susumu Ishida |
| author_sort | Akihiro Shinkai |
| collection | DOAJ |
| description | Abstract Background The relationship between anti-estrogen drugs and macular telangiectasia type 2 (MacTel-2) remains unknown. Here we report a case with anti-estrogen maculopathy resembling MacTel-2 with improved visual function and macular morphology following cessation of anti-estrogen drugs. Case presentation A 53-year-old woman presented with a 5-month history of central vision loss and anorthopia in both eyes. She had received oral tamoxifen followed by toremifene for 69 months. Funduscopy, fluorescein angiography, and optical coherence tomography (OCT) revealed MacTel-2-like findings OU. Fundus autofluorescence (FAF) showed hyper-autofluorescence at the fovea OU. Visual acuity, macular morphology on OCT, and FAF findings gradually improved after cessation of anti-estrogen drugs. Conclusions In the present case, visual acuity, macular morphology, and impairment of the retinal pigment epithelium (RPE) improved following cessation of anti-estrogen drugs, suggesting the relationship between retinal toxicity of anti-estrogen drugs and the development of MacTel-2-like findings. From these results and the previous observations, toxicity of both photoreceptor and RPE cells caused by anti-estrogen drugs may contribute to the development of anti-estrogen maculopathy similar to MacTel-2. |
| first_indexed | 2024-12-14T15:07:12Z |
| format | Article |
| id | doaj.art-f850e8cba5dc4e1d80dd11a1a9cabd09 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-14T15:07:12Z |
| publishDate | 2019-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-f850e8cba5dc4e1d80dd11a1a9cabd092022-12-21T22:56:40ZengBMCBMC Ophthalmology1471-24152019-12-011911410.1186/s12886-019-1280-1Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesisAkihiro Shinkai0Wataru Saito1Yuki Hashimoto2Susumu Ishida3Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityAbstract Background The relationship between anti-estrogen drugs and macular telangiectasia type 2 (MacTel-2) remains unknown. Here we report a case with anti-estrogen maculopathy resembling MacTel-2 with improved visual function and macular morphology following cessation of anti-estrogen drugs. Case presentation A 53-year-old woman presented with a 5-month history of central vision loss and anorthopia in both eyes. She had received oral tamoxifen followed by toremifene for 69 months. Funduscopy, fluorescein angiography, and optical coherence tomography (OCT) revealed MacTel-2-like findings OU. Fundus autofluorescence (FAF) showed hyper-autofluorescence at the fovea OU. Visual acuity, macular morphology on OCT, and FAF findings gradually improved after cessation of anti-estrogen drugs. Conclusions In the present case, visual acuity, macular morphology, and impairment of the retinal pigment epithelium (RPE) improved following cessation of anti-estrogen drugs, suggesting the relationship between retinal toxicity of anti-estrogen drugs and the development of MacTel-2-like findings. From these results and the previous observations, toxicity of both photoreceptor and RPE cells caused by anti-estrogen drugs may contribute to the development of anti-estrogen maculopathy similar to MacTel-2.https://doi.org/10.1186/s12886-019-1280-1Macular telangiectasia type 2PhotoreceptorTamoxifenRetinal pigment epitheliumToremifeneToxicity |
| spellingShingle | Akihiro Shinkai Wataru Saito Yuki Hashimoto Susumu Ishida Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis BMC Ophthalmology Macular telangiectasia type 2 Photoreceptor Tamoxifen Retinal pigment epithelium Toremifene Toxicity |
| title | Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis |
| title_full | Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis |
| title_fullStr | Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis |
| title_full_unstemmed | Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis |
| title_short | Improvements in visual acuity and macular morphology following cessation of anti-estrogen drugs in a patient with anti-estrogen maculopathy resembling macular telangiectasia type 2: a pathogenic hypothesis |
| title_sort | improvements in visual acuity and macular morphology following cessation of anti estrogen drugs in a patient with anti estrogen maculopathy resembling macular telangiectasia type 2 a pathogenic hypothesis |
| topic | Macular telangiectasia type 2 Photoreceptor Tamoxifen Retinal pigment epithelium Toremifene Toxicity |
| url | https://doi.org/10.1186/s12886-019-1280-1 |
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