Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children
Two live attenuated varicella vaccine (VZV) strains have been mainly used across the globe: MAV/06 and OKA strains. We aimed to explore the safety of interchanging the two VZV strains for primary and booster immunizations. South Korea’s vaccine adverse event reporting system (VAERS) was accessed and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/11/9/1442 |
| _version_ | 1797576513612152832 |
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| author | Hyun Mi Kang Gwanglok Kim Young June Choe |
| author_facet | Hyun Mi Kang Gwanglok Kim Young June Choe |
| author_sort | Hyun Mi Kang |
| collection | DOAJ |
| description | Two live attenuated varicella vaccine (VZV) strains have been mainly used across the globe: MAV/06 and OKA strains. We aimed to explore the safety of interchanging the two VZV strains for primary and booster immunizations. South Korea’s vaccine adverse event reporting system (VAERS) was accessed and searched to find filed reports of all adverse events (AEs) following immunization with the second dose of the varicella vaccine. The electronic medical records were reviewed for all visits to the hospital following the second dose of the varicella vaccine. Of the total 406 study participants, 27.5% (n = 112) were in the MAV/06–MAV/06 group, 30.3% (n = 123) in the MAV/06–OKA, 17.5% (n = 71) in the OKA–MAV/06 group, and 24.6% (n = 100) in the OKA–OKA group. Mean age at immunization with the first dose was 1.10 (standard deviation [SD] ±0.34) years old, and second dose was 4.77 (SD ± 1.13) (<i>p</i> = 0.772 and 0.933, respectively). There were no filed reports of AEs following the second dose in the national VAERS. Hospital visit records showed a total of 10.3% (95% confidence interval [CI], 7.6–13.7) (n = 42) had recorded AEs following the 2nd administered dose; however, only 0.7% (95% CI, 0.2–2.4) (n = 3) were regarded as possibly vaccine related. Two patients in the MAV/06–OKA group were diagnosed with Henoch-Schonlein purpura after the second dose; however, both had also received the MMR vaccine on the same day. No safety signals associated with interchanging the MAV/06 and OKA strain live attenuated varicella vaccines were observed in this patient cohort of healthy children. |
| first_indexed | 2024-03-10T21:53:04Z |
| format | Article |
| id | doaj.art-f8519d419dca44bfb6a5495187b35b96 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T21:53:04Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-f8519d419dca44bfb6a5495187b35b962023-11-19T13:19:00ZengMDPI AGVaccines2076-393X2023-08-01119144210.3390/vaccines11091442Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in ChildrenHyun Mi Kang0Gwanglok Kim1Young June Choe2Department of Pediatrics, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of KoreaDepartment of Corporate Development, GC Biopharma Corporation, Yongin 16924, Republic of KoreaDepartment of Pediatrics, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of KoreaTwo live attenuated varicella vaccine (VZV) strains have been mainly used across the globe: MAV/06 and OKA strains. We aimed to explore the safety of interchanging the two VZV strains for primary and booster immunizations. South Korea’s vaccine adverse event reporting system (VAERS) was accessed and searched to find filed reports of all adverse events (AEs) following immunization with the second dose of the varicella vaccine. The electronic medical records were reviewed for all visits to the hospital following the second dose of the varicella vaccine. Of the total 406 study participants, 27.5% (n = 112) were in the MAV/06–MAV/06 group, 30.3% (n = 123) in the MAV/06–OKA, 17.5% (n = 71) in the OKA–MAV/06 group, and 24.6% (n = 100) in the OKA–OKA group. Mean age at immunization with the first dose was 1.10 (standard deviation [SD] ±0.34) years old, and second dose was 4.77 (SD ± 1.13) (<i>p</i> = 0.772 and 0.933, respectively). There were no filed reports of AEs following the second dose in the national VAERS. Hospital visit records showed a total of 10.3% (95% confidence interval [CI], 7.6–13.7) (n = 42) had recorded AEs following the 2nd administered dose; however, only 0.7% (95% CI, 0.2–2.4) (n = 3) were regarded as possibly vaccine related. Two patients in the MAV/06–OKA group were diagnosed with Henoch-Schonlein purpura after the second dose; however, both had also received the MMR vaccine on the same day. No safety signals associated with interchanging the MAV/06 and OKA strain live attenuated varicella vaccines were observed in this patient cohort of healthy children.https://www.mdpi.com/2076-393X/11/9/1442MAV/06safetyvaccinevaricellaOKA |
| spellingShingle | Hyun Mi Kang Gwanglok Kim Young June Choe Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children Vaccines MAV/06 safety vaccine varicella OKA |
| title | Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children |
| title_full | Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children |
| title_fullStr | Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children |
| title_full_unstemmed | Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children |
| title_short | Safety of Interchanging the Live Attenuated MAV/06 Strain and OKA Strain Varicella Vaccines in Children |
| title_sort | safety of interchanging the live attenuated mav 06 strain and oka strain varicella vaccines in children |
| topic | MAV/06 safety vaccine varicella OKA |
| url | https://www.mdpi.com/2076-393X/11/9/1442 |
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