THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION
Aim. To evaluate efficacy and safety of combination antihypertension compound Dalneva® — combination of perindopril and amlodipine by KRKA company in treatment of patients with second stage arterial hypertension (AH).Material and methods. Totally 36 patients included with AH of II stage (20 women,...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2015-09-01
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| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/271 |
| _version_ | 1826561404040118272 |
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| author | E. N. Andreicheva |
| author_facet | E. N. Andreicheva |
| author_sort | E. N. Andreicheva |
| collection | DOAJ |
| description | Aim. To evaluate efficacy and safety of combination antihypertension compound Dalneva® — combination of perindopril and amlodipine by KRKA company in treatment of patients with second stage arterial hypertension (AH).Material and methods. Totally 36 patients included with AH of II stage (20 women, 16 men). Mean age was 56,4±2,6 y; duration of hypertension anamnesis — 8,2±1,9 y. All patients had noncontrolled AH on the previous treatment. Compliance to previously prescribed medications was low — 55,5% of patients did not take the drugs on regular basis. At the moment of study inclusion the mean systolic BP (SBP) was 166,6±28,1 mmHg, mean diastolic BP (DBP) — 90,6±11,4 mmHg. All patients were assigned the Dalneva® in various dosages: from 4/5 mg to 8/10 once per day, relating baseline condition. Efficacy of treatment was evaluated by BP level in office visits and by selfcontrol. Respectively, the correction of dosages was done. For life quality assessment, we used EQ5D and VAS before the beginning of drug intake and in 3 months of treatment. Drug tolerability was assessed with the clinical condition questionnaire CGI-I.Results. In 3 months of therapy the mean SBP was 138,5±13,4 mmHg (p=0,001), mean DBP — 80,4±6,1 mmHg (p=0,001). Side effects, such as dry cough and peripheral edema, specific for the drug components, were not registered. The dynamics of values: by VAS — 61,2±3,8; in 3 months 72,6±3,3 (p<0,05); by EQ5D the activity, self-help at the baseline were high and did not change in Dalneva® group. CGI-I showed: 31 patients marked “significant improvement”, 2 — “very significant improvement”, 3 — minimal improvement”. The treatment by Dalneva® continued 91,6% of patients.Conclusion. Hypotension drug Dalneva® — the fixed combination of perindopril and amlodipine — is safe and effective against AH of II stage. Once per day intake makes it comfortable and improves compliance. |
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| id | doaj.art-f8528be0922e45af89c59913e272de8e |
| institution | Directory Open Access Journal |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| last_indexed | 2025-03-14T09:31:38Z |
| publishDate | 2015-09-01 |
| publisher | «FIRMA «SILICEA» LLC |
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| series | Российский кардиологический журнал |
| spelling | doaj.art-f8528be0922e45af89c59913e272de8e2025-03-02T11:42:37Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202015-09-0109596410.15829/1560-4071-2015-9-59-64271THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSIONE. N. Andreicheva0Kazan State Medical UniversityAim. To evaluate efficacy and safety of combination antihypertension compound Dalneva® — combination of perindopril and amlodipine by KRKA company in treatment of patients with second stage arterial hypertension (AH).Material and methods. Totally 36 patients included with AH of II stage (20 women, 16 men). Mean age was 56,4±2,6 y; duration of hypertension anamnesis — 8,2±1,9 y. All patients had noncontrolled AH on the previous treatment. Compliance to previously prescribed medications was low — 55,5% of patients did not take the drugs on regular basis. At the moment of study inclusion the mean systolic BP (SBP) was 166,6±28,1 mmHg, mean diastolic BP (DBP) — 90,6±11,4 mmHg. All patients were assigned the Dalneva® in various dosages: from 4/5 mg to 8/10 once per day, relating baseline condition. Efficacy of treatment was evaluated by BP level in office visits and by selfcontrol. Respectively, the correction of dosages was done. For life quality assessment, we used EQ5D and VAS before the beginning of drug intake and in 3 months of treatment. Drug tolerability was assessed with the clinical condition questionnaire CGI-I.Results. In 3 months of therapy the mean SBP was 138,5±13,4 mmHg (p=0,001), mean DBP — 80,4±6,1 mmHg (p=0,001). Side effects, such as dry cough and peripheral edema, specific for the drug components, were not registered. The dynamics of values: by VAS — 61,2±3,8; in 3 months 72,6±3,3 (p<0,05); by EQ5D the activity, self-help at the baseline were high and did not change in Dalneva® group. CGI-I showed: 31 patients marked “significant improvement”, 2 — “very significant improvement”, 3 — minimal improvement”. The treatment by Dalneva® continued 91,6% of patients.Conclusion. Hypotension drug Dalneva® — the fixed combination of perindopril and amlodipine — is safe and effective against AH of II stage. Once per day intake makes it comfortable and improves compliance.https://russjcardiol.elpub.ru/jour/article/view/271systemic hypertensioncombination treatmentdalneva® |
| spellingShingle | E. N. Andreicheva THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION Российский кардиологический журнал systemic hypertension combination treatment dalneva® |
| title | THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION |
| title_full | THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION |
| title_fullStr | THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION |
| title_full_unstemmed | THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION |
| title_short | THE USE OF FIXED COMBINATION OF PERINDOPRIL AND AMLODIPINE IN 2ND STAGE ARTERIAL HYPERTENSION |
| title_sort | use of fixed combination of perindopril and amlodipine in 2nd stage arterial hypertension |
| topic | systemic hypertension combination treatment dalneva® |
| url | https://russjcardiol.elpub.ru/jour/article/view/271 |
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