RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction
The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18022-6 |
| _version_ | 1818692336587112448 |
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| author | Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed |
| author_facet | Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed |
| author_sort | Mauro Montalbano |
| collection | DOAJ |
| description | The Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy. |
| first_indexed | 2024-12-17T12:56:10Z |
| format | Article |
| id | doaj.art-f852a7fca4c646d8bcc24eb27d1af230 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:56:10Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f852a7fca4c646d8bcc24eb27d1af2302022-12-21T21:47:28ZengNature PortfolioNature Communications2041-17232020-08-0111111610.1038/s41467-020-18022-6RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunctionMauro Montalbano0Salome McAllen1Nicha Puangmalai2Urmi Sengupta3Nemil Bhatt4Omar D. Johnson5Michael G. Kharas6Rakez Kayed7Mitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchSchool of Medicine, University of Texas Medical BranchDivision of Molecular Pharmacology, Memorial Sloan Kettering Institute Cancer CenterMitchell Center for Neurodegenerative Diseases, University of Texas Medical BranchThe Musashi family of RNA binding proteins are found in an oligomeric state in the brains of patients with Alzheimer’s disease. Here the authors show that Mushashi1 and Musashi2 interact with tau protein in patient tissue and in models of tauopathy.https://doi.org/10.1038/s41467-020-18022-6 |
| spellingShingle | Mauro Montalbano Salome McAllen Nicha Puangmalai Urmi Sengupta Nemil Bhatt Omar D. Johnson Michael G. Kharas Rakez Kayed RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction Nature Communications |
| title | RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
| title_full | RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
| title_fullStr | RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
| title_full_unstemmed | RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
| title_short | RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction |
| title_sort | rna binding proteins musashi and tau soluble aggregates initiate nuclear dysfunction |
| url | https://doi.org/10.1038/s41467-020-18022-6 |
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