Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells
<p>Abstract</p> <p>Background</p> <p>Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2009-11-01
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| Series: | BMC Cancer |
| Online Access: | http://www.biomedcentral.com/1471-2407/9/414 |
| _version_ | 1811287415395975168 |
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| author | Suzuki Kazuhiro Ito Kazuto Suradji Eka W Yamazaki Chiho Kobayashi Kenji Faried Ahmad Abdulah Rizky Murakami Masami Kuwano Hiroyuki Koyama Hiroshi |
| author_facet | Suzuki Kazuhiro Ito Kazuto Suradji Eka W Yamazaki Chiho Kobayashi Kenji Faried Ahmad Abdulah Rizky Murakami Masami Kuwano Hiroyuki Koyama Hiroshi |
| author_sort | Suzuki Kazuhiro |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts.</p> <p>Method</p> <p>Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract.</p> <p>Results</p> <p>Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway.</p> <p>Conclusion</p> <p>Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy.</p> |
| first_indexed | 2024-04-13T03:18:05Z |
| format | Article |
| id | doaj.art-f85502ed701a45d99e7c10c18c43de2f |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-04-13T03:18:05Z |
| publishDate | 2009-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-f85502ed701a45d99e7c10c18c43de2f2022-12-22T03:04:51ZengBMCBMC Cancer1471-24072009-11-019141410.1186/1471-2407-9-414Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cellsSuzuki KazuhiroIto KazutoSuradji Eka WYamazaki ChihoKobayashi KenjiFaried AhmadAbdulah RizkyMurakami MasamiKuwano HiroyukiKoyama Hiroshi<p>Abstract</p> <p>Background</p> <p>Broccoli is a Brassica vegetable that is believed to possess chemopreventive properties. Selenium also shows promise as an anticancer agent. Thus, selenium enrichment of broccoli has the potential to enhance the anticancer properties of broccoli sprouts.</p> <p>Method</p> <p>Selenium-enriched broccoli sprouts were prepared using a sodium selenite solution. Their anticancer properties were evaluated in human prostate cancer cell lines and compared with those of a control broccoli sprout extract.</p> <p>Results</p> <p>Selenium-enriched broccoli sprouts were superior to normal broccoli sprouts in inhibiting cell proliferation, decreasing prostate-specific antigen secretion, and inducing apoptosis of prostate cancer cells. Furthermore, selenium-enriched broccoli sprouts but, not normal broccoli sprouts, induced a downregulation of the survival Akt/mTOR pathway.</p> <p>Conclusion</p> <p>Our results suggest that selenium-enriched broccoli sprouts could potentially be used as an alternative selenium source for prostate cancer prevention and therapy.</p>http://www.biomedcentral.com/1471-2407/9/414 |
| spellingShingle | Suzuki Kazuhiro Ito Kazuto Suradji Eka W Yamazaki Chiho Kobayashi Kenji Faried Ahmad Abdulah Rizky Murakami Masami Kuwano Hiroyuki Koyama Hiroshi Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells BMC Cancer |
| title | Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells |
| title_full | Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells |
| title_fullStr | Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells |
| title_full_unstemmed | Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells |
| title_short | Selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of LNCaP prostate cancer cells |
| title_sort | selenium enrichment of broccoli sprout extract increases chemosensitivity and apoptosis of lncap prostate cancer cells |
| url | http://www.biomedcentral.com/1471-2407/9/414 |
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