CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells

CSF1R Inhibition Combined with GM-CSF Reprograms Macrophages and Disrupts Protumoral Interplays with AML Cells

Relapse is a major issue in acute myeloid leukemia (AML) and while the contribution of gene mutations in developing drug resistance is well established, little is known on the role of macrophages (MΦs) in an AML cell microenvironment. We examined whether myeloblasts could educate MΦs to adopt a prot...

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Bibliographic Details
Main Authors: Tatiana Smirnova, Caroline Spertini, Olivier Spertini
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Cancers
Subjects:
AML
macrophages
M-CSF
CSF1 receptor
GM-CSF
CD163
Online Access:https://www.mdpi.com/2072-6694/13/21/5289

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