The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats
Objective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiter...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2013-07-01
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| Series: | Avicenna Journal of Phytomedicine |
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| Online Access: | http://ajp.mums.ac.ir/pdf_766_7ab1dd93b910478ff0ee8843a7faa0a4.html |
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| author | Azam Rezaei Shahnaz ShekarForoush Saeed Changizi Ashtiyani Hydar Aqababa Ali Zarei Maryam Azizi Hasan Yarmahmodi |
| author_facet | Azam Rezaei Shahnaz ShekarForoush Saeed Changizi Ashtiyani Hydar Aqababa Ali Zarei Maryam Azizi Hasan Yarmahmodi |
| author_sort | Azam Rezaei |
| collection | DOAJ |
| description | Objective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the effects of Artemisia plant extract on thioacetamide-induced hepatotoxicity in Wistar rats. Materials and Methods: For induction of hepatotoxicity, 50 mg/kg thioacetamide was injected intraperitoneally (i.p).After extraction and purification, the hydroalcoholicextract was injected i.p. at 100, 200, and 300 mg/kg doses for 21 days together with thioacetamide at 50 mg/kg dose in the last 3 days. After blood sampling and separation of serum, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, and total protein concentrations were measured. Results: Significant decreases in aminotransferase and alkaline phosphatase activities and significant increases in the concentration of albumin and total protein in groups treated with the extract compared with thioacetamide-treated group were observed (p |
| first_indexed | 2024-04-12T20:43:16Z |
| format | Article |
| id | doaj.art-f857dfcd45ab41b4a21fbcebf5dbadce |
| institution | Directory Open Access Journal |
| issn | 2228-7930 2228-7949 |
| language | English |
| last_indexed | 2024-04-12T20:43:16Z |
| publishDate | 2013-07-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Avicenna Journal of Phytomedicine |
| spelling | doaj.art-f857dfcd45ab41b4a21fbcebf5dbadce2022-12-22T03:17:21ZengMashhad University of Medical SciencesAvicenna Journal of Phytomedicine2228-79302228-79492013-07-0134293301766The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male ratsAzam Rezaei0Shahnaz ShekarForoush1Saeed Changizi Ashtiyani2Hydar Aqababa3Ali Zarei4Maryam Azizi5Hasan Yarmahmodi6Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, I. R. IranDepartment of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, I. R. IranDepartment of Physiology, Arak University of Medical Sciences, Arak, I. R. IranDepartment of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, I. R. IranDepartment of Biology, Damghan Branch, Islamic Azad University, Damghan, I. R. IranDepartment of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, I. R. IranDepartment of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, I. R. IranObjective: Liver is an important organ that is exposed to many oxidant and carcinogenic agents, thus antioxidant compounds are beneficial for liver health. Artemisia contains flavonoid compounds and anti-diabetic, antioxidant, and anti-inflammatory properties. Due to possessing terpene and sesquiterpene compounds, this plant has antioxidant properties. This study was done to investigate the effects of Artemisia plant extract on thioacetamide-induced hepatotoxicity in Wistar rats. Materials and Methods: For induction of hepatotoxicity, 50 mg/kg thioacetamide was injected intraperitoneally (i.p).After extraction and purification, the hydroalcoholicextract was injected i.p. at 100, 200, and 300 mg/kg doses for 21 days together with thioacetamide at 50 mg/kg dose in the last 3 days. After blood sampling and separation of serum, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), albumin, and total protein concentrations were measured. Results: Significant decreases in aminotransferase and alkaline phosphatase activities and significant increases in the concentration of albumin and total protein in groups treated with the extract compared with thioacetamide-treated group were observed (phttp://ajp.mums.ac.ir/pdf_766_7ab1dd93b910478ff0ee8843a7faa0a4.htmlArtemisiaHepato-protectivePhenolic compoundsRatThioacetamide |
| spellingShingle | Azam Rezaei Shahnaz ShekarForoush Saeed Changizi Ashtiyani Hydar Aqababa Ali Zarei Maryam Azizi Hasan Yarmahmodi The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats Avicenna Journal of Phytomedicine Artemisia Hepato-protective Phenolic compounds Rat Thioacetamide |
| title | The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats |
| title_full | The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats |
| title_fullStr | The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats |
| title_full_unstemmed | The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats |
| title_short | The effects of Artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats |
| title_sort | effects of artemisia aucheri extract on hepatotoxicity induced by thioacetamide in male rats |
| topic | Artemisia Hepato-protective Phenolic compounds Rat Thioacetamide |
| url | http://ajp.mums.ac.ir/pdf_766_7ab1dd93b910478ff0ee8843a7faa0a4.html |
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