The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients
Background: Liver transplantation (LT) increases the risk of de novo malignancies including skin cancers. However, risk factors for this type of cancers have not been well studied.Objective: To determine the incidence of skin cancer in LT recipients, and to identify the risk factors of this type of...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2012-10-01
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| Series: | International Journal of Organ Transplantation Medicine |
| Subjects: | |
| Online Access: | http://home.sums.ac.ir/~habibzaf/ojs/index.php/IJOTM/article/view/135/238 |
| _version_ | 1818303867281997824 |
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| author | JM Modaresi Esfeh M Pagadala R Lopez A Tabba D Dalal IA Hanouneh B Eghtesad NN Zein |
| author_facet | JM Modaresi Esfeh M Pagadala R Lopez A Tabba D Dalal IA Hanouneh B Eghtesad NN Zein |
| author_sort | JM Modaresi Esfeh |
| collection | DOAJ |
| description | Background: Liver transplantation (LT) increases the risk of de novo malignancies including skin cancers. However, risk factors for this type of cancers have not been well studied.Objective: To determine the incidence of skin cancer in LT recipients, and to identify the risk factors of this type of cancer.Methods: We identified all adult patients who underwent LT and developed de novo skin cancer post-LT at our institution between 1996 and 2009. We excluded the patients with history of skin cancer prior to LT. We also studied a control group of patients who underwent LT during the same period but did not develop skin cancer; the control group was matched (1:2) for age, gender and geographical place of residence.Results: Over a median (IQR) follow-up of 41.5 (18.0, 98.6) months, 23 (2.3%) of 998 patients developed skin cancer post-LT, of whom 10 were identified with squamous cell carcinoma, 9 with basal cell carcinoma and 4 with melanoma. After adjusting the confounding variables, subjects who had combined liver/kidney transplant had 22 (95% CI: 5.1–99) times higher hazard of skin cancer compared to subjects with LT alone. Furthermore, patients who had non-skin cancer prior to LT had 23 (95% CI: 8.6–60) times higher hazard developing skin cancer after the transplant. Patients with history of alcohol consumption, as the underlying etiology of liver disease, had 4 (95% CI: 1.2–12.9) times higher hazard of developing skin cancer after transplantation. Type or duration of immunosuppression was not associated with increased risk of skin cancer post-LT. The post-LT survival outcome was not affected by the development of de novo skin cancer post-LT.Conclusion: Skin cancer is relatively common in LT recipients and should be monitored, particularly in patients with a history of pretransplant malignancy, recipients of combined liver and kidney transplant or having alcoholic cirrhosis as the underlying cause of liver disease. |
| first_indexed | 2024-12-13T06:01:37Z |
| format | Article |
| id | doaj.art-f858ace2be834c5bb1cd8539cc5890e2 |
| institution | Directory Open Access Journal |
| issn | 2008-6490 2008-6482 |
| language | English |
| last_indexed | 2024-12-13T06:01:37Z |
| publishDate | 2012-10-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | International Journal of Organ Transplantation Medicine |
| spelling | doaj.art-f858ace2be834c5bb1cd8539cc5890e22022-12-21T23:57:20ZengShiraz University of Medical SciencesInternational Journal of Organ Transplantation Medicine2008-64902008-64822012-10-0134157163The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant RecipientsJM Modaresi EsfehM PagadalaR LopezA TabbaD DalalIA HanounehB EghtesadNN ZeinBackground: Liver transplantation (LT) increases the risk of de novo malignancies including skin cancers. However, risk factors for this type of cancers have not been well studied.Objective: To determine the incidence of skin cancer in LT recipients, and to identify the risk factors of this type of cancer.Methods: We identified all adult patients who underwent LT and developed de novo skin cancer post-LT at our institution between 1996 and 2009. We excluded the patients with history of skin cancer prior to LT. We also studied a control group of patients who underwent LT during the same period but did not develop skin cancer; the control group was matched (1:2) for age, gender and geographical place of residence.Results: Over a median (IQR) follow-up of 41.5 (18.0, 98.6) months, 23 (2.3%) of 998 patients developed skin cancer post-LT, of whom 10 were identified with squamous cell carcinoma, 9 with basal cell carcinoma and 4 with melanoma. After adjusting the confounding variables, subjects who had combined liver/kidney transplant had 22 (95% CI: 5.1–99) times higher hazard of skin cancer compared to subjects with LT alone. Furthermore, patients who had non-skin cancer prior to LT had 23 (95% CI: 8.6–60) times higher hazard developing skin cancer after the transplant. Patients with history of alcohol consumption, as the underlying etiology of liver disease, had 4 (95% CI: 1.2–12.9) times higher hazard of developing skin cancer after transplantation. Type or duration of immunosuppression was not associated with increased risk of skin cancer post-LT. The post-LT survival outcome was not affected by the development of de novo skin cancer post-LT.Conclusion: Skin cancer is relatively common in LT recipients and should be monitored, particularly in patients with a history of pretransplant malignancy, recipients of combined liver and kidney transplant or having alcoholic cirrhosis as the underlying cause of liver disease.http://home.sums.ac.ir/~habibzaf/ojs/index.php/IJOTM/article/view/135/238Liver transplantationde novo malignancyskin cancer |
| spellingShingle | JM Modaresi Esfeh M Pagadala R Lopez A Tabba D Dalal IA Hanouneh B Eghtesad NN Zein The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients International Journal of Organ Transplantation Medicine Liver transplantation de novo malignancy skin cancer |
| title | The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients |
| title_full | The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients |
| title_fullStr | The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients |
| title_full_unstemmed | The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients |
| title_short | The Incidence and Risk Factors of De Novo Skin Cancer in the Liver Transplant Recipients |
| title_sort | incidence and risk factors of de novo skin cancer in the liver transplant recipients |
| topic | Liver transplantation de novo malignancy skin cancer |
| url | http://home.sums.ac.ir/~habibzaf/ojs/index.php/IJOTM/article/view/135/238 |
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