Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia
Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in chi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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European Respiratory Society
2020-09-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/6/3/00210-2019.full |
| _version_ | 1829112823725162496 |
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| author | Valentina Ferraro Eleni-Rosalina Andrinopoulou Anna Marthe Margaretha Sijbring Eric G. Haarman Harm A.W.M. Tiddens Marielle W.H. Pijnenburg |
| author_facet | Valentina Ferraro Eleni-Rosalina Andrinopoulou Anna Marthe Margaretha Sijbring Eric G. Haarman Harm A.W.M. Tiddens Marielle W.H. Pijnenburg |
| author_sort | Valentina Ferraro |
| collection | DOAJ |
| description | Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in children with PCD. The objectives of the present study were to quantify airway and artery dimensions on chest CT in a cohort of children with PCD and compare these with control children to analyse the influence of covariates on airway and artery dimensions. Chest CTs of 13 children with PCD (14 CT scans) and 12 control children were collected retrospectively. The bronchial tree was segmented semi-automatically and reconstructed in a three-dimensional view. All visible airway–artery (AA) pairs were measured perpendicular to the airway centre line, annotating per branch inner and outer airway and adjacent artery diameter and computing inner airway diameter/artery ratio (AinA ratio), outer airway diameter/artery ratio (AoutA ratio), wall thickness (WT), WT/outer airway diameter ratio (Awt ratio) and WT/artery ratio. In the children with PCD (38.5% male, mean age 13.5 years, range 9.8–15.3) 1526 AA pairs were measured versus 1516 in controls (58.3% male, mean age 13.5 years, range 8–14.8). AinA ratio and AoutA ratio were significantly higher in children with PCD than in control children (both p<0.001). Awt ratio was significantly higher in control children than in children with PCD (p<0.001). Our study showed that in children with PCD airways are more dilated than in controls and do not show airway wall thickening. |
| first_indexed | 2024-12-12T15:24:49Z |
| format | Article |
| id | doaj.art-f85a6e3ce8284c92904d58b7afab2d38 |
| institution | Directory Open Access Journal |
| issn | 2312-0541 |
| language | English |
| last_indexed | 2024-12-12T15:24:49Z |
| publishDate | 2020-09-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | ERJ Open Research |
| spelling | doaj.art-f85a6e3ce8284c92904d58b7afab2d382022-12-22T00:20:18ZengEuropean Respiratory SocietyERJ Open Research2312-05412020-09-016310.1183/23120541.00210-201900210-2019Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesiaValentina Ferraro0Eleni-Rosalina Andrinopoulou1Anna Marthe Margaretha Sijbring2Eric G. Haarman3Harm A.W.M. Tiddens4Marielle W.H. Pijnenburg5 Unit of Pediatric Allergy and Respiratory Medicine, Dept of Women's and Children's Health, University of Padua, Padua, Italy Dept of Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Dept of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Dept of Pediatric Pulmonology, VU University Medical Center, Amsterdam, The Netherlands Dept of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Dept of Pediatrics, Division of Respiratory Medicine and Allergology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Chest computed tomography (CT) is the gold standard for detecting structural abnormalities in patients with primary ciliary dyskinesia (PCD) such as bronchiectasis, bronchial wall thickening and mucus plugging. There are no studies on quantitative assessment of airway and artery abnormalities in children with PCD. The objectives of the present study were to quantify airway and artery dimensions on chest CT in a cohort of children with PCD and compare these with control children to analyse the influence of covariates on airway and artery dimensions. Chest CTs of 13 children with PCD (14 CT scans) and 12 control children were collected retrospectively. The bronchial tree was segmented semi-automatically and reconstructed in a three-dimensional view. All visible airway–artery (AA) pairs were measured perpendicular to the airway centre line, annotating per branch inner and outer airway and adjacent artery diameter and computing inner airway diameter/artery ratio (AinA ratio), outer airway diameter/artery ratio (AoutA ratio), wall thickness (WT), WT/outer airway diameter ratio (Awt ratio) and WT/artery ratio. In the children with PCD (38.5% male, mean age 13.5 years, range 9.8–15.3) 1526 AA pairs were measured versus 1516 in controls (58.3% male, mean age 13.5 years, range 8–14.8). AinA ratio and AoutA ratio were significantly higher in children with PCD than in control children (both p<0.001). Awt ratio was significantly higher in control children than in children with PCD (p<0.001). Our study showed that in children with PCD airways are more dilated than in controls and do not show airway wall thickening.http://openres.ersjournals.com/content/6/3/00210-2019.full |
| spellingShingle | Valentina Ferraro Eleni-Rosalina Andrinopoulou Anna Marthe Margaretha Sijbring Eric G. Haarman Harm A.W.M. Tiddens Marielle W.H. Pijnenburg Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia ERJ Open Research |
| title | Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia |
| title_full | Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia |
| title_fullStr | Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia |
| title_full_unstemmed | Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia |
| title_short | Airway–artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia |
| title_sort | airway artery quantitative assessment on chest computed tomography in paediatric primary ciliary dyskinesia |
| url | http://openres.ersjournals.com/content/6/3/00210-2019.full |
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