Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E–Deficient Mice

Glycoursodeoxycholic Acid Ameliorates Atherosclerosis and Alters Gut Microbiota in Apolipoprotein E–Deficient Mice

Background Although glycoursodeoxycholic acid (GUDCA) has been associated with the improvement of metabolic disorders, its effect on atherosclerosis remains elusive. This study aimed to investigate the role of GUDCA in the development of atherosclerosis and its potential mechanisms. Methods and Resu...

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Bibliographic Details
Main Authors: Kan Huang, Chenshu Liu, Meixiu Peng, Qiao Su, Ruiming Liu, Zeling Guo, Sifan Chen, Zilun Li, Guangqi Chang
Format: Article
Language:English
Published: Wiley 2021-04-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
atherosclerosis
cholesterol homeostasis
foam cell
glycoursodeoxycholic acid
gut microbiota
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.019820

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