Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application
Febuxostat, initially developed as a xanthine oxidase inhibitor to address hyperuricemia in gout patients, has evolved into a versatile therapeutic agent with multifaceted applications. This review provides a comprehensive overview of febuxostat’s mechanism of action, its effectiveness in gout manag...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/11/2199 |
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| author | Krasimir Iliev Kraev Mariela Gencheva Geneva-Popova Bozhidar Krasimirov Hristov Petar Angelov Uchikov Stanislava Dimitrova Popova-Belova Maria Ilieva Kraeva Yordanka Mincheva Basheva-Kraeva Nina Staneva Stoyanova Vesela Todorova Mitkova-Hristova |
| author_facet | Krasimir Iliev Kraev Mariela Gencheva Geneva-Popova Bozhidar Krasimirov Hristov Petar Angelov Uchikov Stanislava Dimitrova Popova-Belova Maria Ilieva Kraeva Yordanka Mincheva Basheva-Kraeva Nina Staneva Stoyanova Vesela Todorova Mitkova-Hristova |
| author_sort | Krasimir Iliev Kraev |
| collection | DOAJ |
| description | Febuxostat, initially developed as a xanthine oxidase inhibitor to address hyperuricemia in gout patients, has evolved into a versatile therapeutic agent with multifaceted applications. This review provides a comprehensive overview of febuxostat’s mechanism of action, its effectiveness in gout management, its cardiovascular safety profile, renal and hepatic effects, musculoskeletal applications, safety considerations, and emerging research prospects. Febuxostat’s primary mechanism involves selective inhibition of xanthine oxidase, resulting in reduced uric acid production. Its pharmacokinetics require personalized dosing strategies based on individual characteristics. In gout management, febuxostat offers a compelling alternative, effectively lowering uric acid levels, relieving symptoms, and supporting long-term control, especially for patients intolerant to allopurinol. Recent studies have demonstrated its cardiovascular safety, and it exhibits minimal hepatotoxicity, making it suitable for those with liver comorbidities. Febuxostat’s potential nephroprotective effects and kidney stone prevention properties are noteworthy, particularly for gout patients with renal concerns. Beyond gout, its anti-inflammatory properties hint at applications in musculoskeletal conditions and a broader spectrum of clinical contexts, including metabolic syndrome. Emerging research explores febuxostat’s roles in cardiovascular health, neurological disorders, rheumatoid arthritis, and cancer therapy, driven by its anti-inflammatory and antioxidative properties. Future directions include personalized medicine, combination therapies, mechanistic insights, and ongoing long-term safety monitoring, collectively illuminating the promising landscape of febuxostat’s multifaceted therapeutic potential. |
| first_indexed | 2024-03-09T16:40:39Z |
| format | Article |
| id | doaj.art-f85b150daecf4843971be4d6ca6575bc |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T16:40:39Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f85b150daecf4843971be4d6ca6575bc2023-11-24T14:52:33ZengMDPI AGLife2075-17292023-11-011311219910.3390/life13112199Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic ApplicationKrasimir Iliev Kraev0Mariela Gencheva Geneva-Popova1Bozhidar Krasimirov Hristov2Petar Angelov Uchikov3Stanislava Dimitrova Popova-Belova4Maria Ilieva Kraeva5Yordanka Mincheva Basheva-Kraeva6Nina Staneva Stoyanova7Vesela Todorova Mitkova-Hristova8Department of Propedeutics of Internal Diseases, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Propedeutics of Internal Diseases, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaSecond Department of Internal Diseases, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaDepartment of Special Surgery, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaDepartment of Propedeutics of Internal Diseases, Medical Faculty, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Otorhynolaryngology, Medical Faculty, Medical University of Plovdiv, 6000 Plovdiv, BulgariaDepartment of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaDepartment of Ophthalmology, Faculty of Medicine, Medical University of Plovdiv, 4000 Plovdiv, BulgariaFebuxostat, initially developed as a xanthine oxidase inhibitor to address hyperuricemia in gout patients, has evolved into a versatile therapeutic agent with multifaceted applications. This review provides a comprehensive overview of febuxostat’s mechanism of action, its effectiveness in gout management, its cardiovascular safety profile, renal and hepatic effects, musculoskeletal applications, safety considerations, and emerging research prospects. Febuxostat’s primary mechanism involves selective inhibition of xanthine oxidase, resulting in reduced uric acid production. Its pharmacokinetics require personalized dosing strategies based on individual characteristics. In gout management, febuxostat offers a compelling alternative, effectively lowering uric acid levels, relieving symptoms, and supporting long-term control, especially for patients intolerant to allopurinol. Recent studies have demonstrated its cardiovascular safety, and it exhibits minimal hepatotoxicity, making it suitable for those with liver comorbidities. Febuxostat’s potential nephroprotective effects and kidney stone prevention properties are noteworthy, particularly for gout patients with renal concerns. Beyond gout, its anti-inflammatory properties hint at applications in musculoskeletal conditions and a broader spectrum of clinical contexts, including metabolic syndrome. Emerging research explores febuxostat’s roles in cardiovascular health, neurological disorders, rheumatoid arthritis, and cancer therapy, driven by its anti-inflammatory and antioxidative properties. Future directions include personalized medicine, combination therapies, mechanistic insights, and ongoing long-term safety monitoring, collectively illuminating the promising landscape of febuxostat’s multifaceted therapeutic potential.https://www.mdpi.com/2075-1729/13/11/2199febuxostathyperuricemiainflammation |
| spellingShingle | Krasimir Iliev Kraev Mariela Gencheva Geneva-Popova Bozhidar Krasimirov Hristov Petar Angelov Uchikov Stanislava Dimitrova Popova-Belova Maria Ilieva Kraeva Yordanka Mincheva Basheva-Kraeva Nina Staneva Stoyanova Vesela Todorova Mitkova-Hristova Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application Life febuxostat hyperuricemia inflammation |
| title | Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application |
| title_full | Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application |
| title_fullStr | Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application |
| title_full_unstemmed | Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application |
| title_short | Celebrating Versatility: Febuxostat’s Multifaceted Therapeutic Application |
| title_sort | celebrating versatility febuxostat s multifaceted therapeutic application |
| topic | febuxostat hyperuricemia inflammation |
| url | https://www.mdpi.com/2075-1729/13/11/2199 |
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