Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation
<p>Abstract</p> <p>Primary splenic diffuse large B-cell lymphoma (DLBCL) is a rare clinical condition, which is generally treated by six to eight cycles of chemotherapy involving a combination of rituximab and the cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP) r...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2012-07-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/150 |
| _version_ | 1818531212781682688 |
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| author | Lin Ying-Chu Chen Hung-Chieh Cheng Shao-Bing Hwang Wen-Li Wang Ren-Ching Teng Chieh-Lin |
| author_facet | Lin Ying-Chu Chen Hung-Chieh Cheng Shao-Bing Hwang Wen-Li Wang Ren-Ching Teng Chieh-Lin |
| author_sort | Lin Ying-Chu |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Primary splenic diffuse large B-cell lymphoma (DLBCL) is a rare clinical condition, which is generally treated by six to eight cycles of chemotherapy involving a combination of rituximab and the cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP) regimen. However, the treatment for chemorefractory primary splenic DLBCL remains controversial. Therapeutic splenic irradiation (SI) might be a reasonable and possibly the only treatment option with curative intention for patients with chemorefractory primary splenic DLBCL. However, the efficacy and safety of therapeutic SI are unclear. Herein, we present the case of a primary splenic DLBCL patient who was refractory to multiple chemotherapy regimens but achieved complete remission after administration of therapeutic SI. However, his condition was complicated with severe gastric variceal bleeding due to splenic venous thrombosis, which was successfully treated via splenectomy and short gastric vein ligation. On the basis of our findings, we concluded that the splenic venous thrombosis-induced gastric variceal bleeding was a rare but life-threatening adverse effect of the therapeutic SI administered for primary splenic DLBCL. Surgical intervention involving splenectomy and short gastric vein ligation is mandatory and should be performed as soon as possible for such patients.</p> |
| first_indexed | 2024-12-11T17:29:31Z |
| format | Article |
| id | doaj.art-f85b62359ad6468babd604116b5faa77 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-11T17:29:31Z |
| publishDate | 2012-07-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-f85b62359ad6468babd604116b5faa772022-12-22T00:56:52ZengBMCWorld Journal of Surgical Oncology1477-78192012-07-0110115010.1186/1477-7819-10-150Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligationLin Ying-ChuChen Hung-ChiehCheng Shao-BingHwang Wen-LiWang Ren-ChingTeng Chieh-Lin<p>Abstract</p> <p>Primary splenic diffuse large B-cell lymphoma (DLBCL) is a rare clinical condition, which is generally treated by six to eight cycles of chemotherapy involving a combination of rituximab and the cyclophosphamide, adriamycin, vincristine, and prednisolone (CHOP) regimen. However, the treatment for chemorefractory primary splenic DLBCL remains controversial. Therapeutic splenic irradiation (SI) might be a reasonable and possibly the only treatment option with curative intention for patients with chemorefractory primary splenic DLBCL. However, the efficacy and safety of therapeutic SI are unclear. Herein, we present the case of a primary splenic DLBCL patient who was refractory to multiple chemotherapy regimens but achieved complete remission after administration of therapeutic SI. However, his condition was complicated with severe gastric variceal bleeding due to splenic venous thrombosis, which was successfully treated via splenectomy and short gastric vein ligation. On the basis of our findings, we concluded that the splenic venous thrombosis-induced gastric variceal bleeding was a rare but life-threatening adverse effect of the therapeutic SI administered for primary splenic DLBCL. Surgical intervention involving splenectomy and short gastric vein ligation is mandatory and should be performed as soon as possible for such patients.</p>http://www.wjso.com/content/10/1/150IrradiationLymphomaSplenectomyThrombosis |
| spellingShingle | Lin Ying-Chu Chen Hung-Chieh Cheng Shao-Bing Hwang Wen-Li Wang Ren-Ching Teng Chieh-Lin Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation World Journal of Surgical Oncology Irradiation Lymphoma Splenectomy Thrombosis |
| title | Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation |
| title_full | Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation |
| title_fullStr | Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation |
| title_full_unstemmed | Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation |
| title_short | Splenic irradiation-induced gastric variceal bleeding in a primary splenic diffuse large B-cell lymphoma patient: a rare complication successfully treated by splenectomy with short gastric vein ligation |
| title_sort | splenic irradiation induced gastric variceal bleeding in a primary splenic diffuse large b cell lymphoma patient a rare complication successfully treated by splenectomy with short gastric vein ligation |
| topic | Irradiation Lymphoma Splenectomy Thrombosis |
| url | http://www.wjso.com/content/10/1/150 |
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