Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients
Alterations in circulating Cu and Zn are negative predictors of survival in neoplastic patients and are known during lung cancer. However, no data on predicting mortality of lung cancer patients based on the level of these elements in the blood have been presented to date. The aims of this prospecti...
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MDPI AG
2020-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/1/60 |
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| author | Katarzyna Zabłocka-Słowińska Anna Prescha Sylwia Płaczkowska Irena Porębska Monika Kosacka Konrad Pawełczyk |
| author_facet | Katarzyna Zabłocka-Słowińska Anna Prescha Sylwia Płaczkowska Irena Porębska Monika Kosacka Konrad Pawełczyk |
| author_sort | Katarzyna Zabłocka-Słowińska |
| collection | DOAJ |
| description | Alterations in circulating Cu and Zn are negative predictors of survival in neoplastic patients and are known during lung cancer. However, no data on predicting mortality of lung cancer patients based on the level of these elements in the blood have been presented to date. The aims of this prospective cohort study were as follows: (i) To evaluate the disturbances in serum and whole blood Cu and Zn, (ii) to assess the relationships between serum and whole blood Cu and Zn status and clinical, sociodemographic, and nutritional data, and (iii) to investigate the association of Cu and Zn status with all-cause mortality in lung cancer. Naïve-treatment lung cancer patients (<i>n</i> = 167) were characterized in terms of sociodemographic, clinical, and anthropometric data and dietary intake and compared with sex-matched control subjects (<i>n</i> = 48). Whole blood and serum Cu and Zn status was determined by atomic absorption spectrometry. Cox proportional hazards models adjusted for multiple confounders/mediators were used to estimate the association between all-cause death and Cu and Zn status. Sex, cardiovascular disease, chronic obstructive pulmonary disease, clinical stage, and hemoglobin, platelet, and glucose concentrations significantly differentiated Cu and Zn status. All-cause mortality in lung cancer patients was positively associated with serum Cu levels, Cu:Zn ratio, and whole blood Zn levels. However, an advanced clinical stage of disease was the strongest predictor of all-cause mortality. Circulatory status of Cu and Zn might be included in routine clinical characteristics of patients with lung cancer patients as additional prognostic variables, but only after further more detail studies. |
| first_indexed | 2024-03-10T13:45:06Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:45:06Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f85b6f39054c42a4b3ee9350e23f22872023-11-21T02:44:08ZengMDPI AGNutrients2072-66432020-12-011316010.3390/nu13010060Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer PatientsKatarzyna Zabłocka-Słowińska0Anna Prescha1Sylwia Płaczkowska2Irena Porębska3Monika Kosacka4Konrad Pawełczyk5Department of Food Science and Dietetics, Wroclaw Medical University, ul. Borowska 211, 50-556 Wroclaw, PolandDepartment of Food Science and Dietetics, Wroclaw Medical University, ul. Borowska 211, 50-556 Wroclaw, PolandDiagnostics Laboratory for Teaching and Research, Department of Laboratory Diagnostics Wroclaw Medical University, ul. Borowska 211a, 50-556 Wroclaw, PolandDepartment and Clinic of Pulmonology and Lung Cancers, Wroclaw Medical University, ul. Grabiszynska 105, 53-439 Wroclaw, PolandDepartment and Clinic of Pulmonology and Lung Cancers, Wroclaw Medical University, ul. Grabiszynska 105, 53-439 Wroclaw, PolandDepartment and Clinic of Thoracic Surgery, Wroclaw Medical University, ul. Grabiszynska 105, 53-439 Wroclaw, PolandAlterations in circulating Cu and Zn are negative predictors of survival in neoplastic patients and are known during lung cancer. However, no data on predicting mortality of lung cancer patients based on the level of these elements in the blood have been presented to date. The aims of this prospective cohort study were as follows: (i) To evaluate the disturbances in serum and whole blood Cu and Zn, (ii) to assess the relationships between serum and whole blood Cu and Zn status and clinical, sociodemographic, and nutritional data, and (iii) to investigate the association of Cu and Zn status with all-cause mortality in lung cancer. Naïve-treatment lung cancer patients (<i>n</i> = 167) were characterized in terms of sociodemographic, clinical, and anthropometric data and dietary intake and compared with sex-matched control subjects (<i>n</i> = 48). Whole blood and serum Cu and Zn status was determined by atomic absorption spectrometry. Cox proportional hazards models adjusted for multiple confounders/mediators were used to estimate the association between all-cause death and Cu and Zn status. Sex, cardiovascular disease, chronic obstructive pulmonary disease, clinical stage, and hemoglobin, platelet, and glucose concentrations significantly differentiated Cu and Zn status. All-cause mortality in lung cancer patients was positively associated with serum Cu levels, Cu:Zn ratio, and whole blood Zn levels. However, an advanced clinical stage of disease was the strongest predictor of all-cause mortality. Circulatory status of Cu and Zn might be included in routine clinical characteristics of patients with lung cancer patients as additional prognostic variables, but only after further more detail studies.https://www.mdpi.com/2072-6643/13/1/60lung cancerzinccopperoverall survival |
| spellingShingle | Katarzyna Zabłocka-Słowińska Anna Prescha Sylwia Płaczkowska Irena Porębska Monika Kosacka Konrad Pawełczyk Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients Nutrients lung cancer zinc copper overall survival |
| title | Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients |
| title_full | Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients |
| title_fullStr | Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients |
| title_full_unstemmed | Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients |
| title_short | Serum and Whole Blood Cu and Zn Status in Predicting Mortality in Lung Cancer Patients |
| title_sort | serum and whole blood cu and zn status in predicting mortality in lung cancer patients |
| topic | lung cancer zinc copper overall survival |
| url | https://www.mdpi.com/2072-6643/13/1/60 |
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