A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis
Abstract Background Anterior chamber flare reaction refers to the light reflection from the protein in aqueous humor. We report a case of very severe flare reaction observed in human leukocyte antigen (HLA)- B27 associated acute anterior uveitis (AAU). Case presentation An age 43 male patient visite...
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | BMC Ophthalmology |
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| Online Access: | http://link.springer.com/article/10.1186/s12886-020-01472-3 |
| _version_ | 1818428863075581952 |
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| author | Jae-Ik Kim Choul Yong Park |
| author_facet | Jae-Ik Kim Choul Yong Park |
| author_sort | Jae-Ik Kim |
| collection | DOAJ |
| description | Abstract Background Anterior chamber flare reaction refers to the light reflection from the protein in aqueous humor. We report a case of very severe flare reaction observed in human leukocyte antigen (HLA)- B27 associated acute anterior uveitis (AAU). Case presentation An age 43 male patient visited the uveitis clinic complaining of decreased visual acuity in the right eye which developed 1 week before. The detailed ophthalmic examination revealed very severe flare reaction in the anterior chamber with diffuse conjunctival hyperemia in the right eye. Pupil margin and iris details were barely observable. Oral prednisolone 20 mg daily with topical 1% prednisolone acetate (Pred Forte, Allergan, CA) every 2 h and 1% topical cyclopentolate (Cyclogyl, Alcon, TX) three times daily were immediately prescribed. The next day, the flare reaction of the right eye decreased significantly and inflammatory cells in the anterior chamber were visible. Detailed fundus examination revealed no inflammatory signs on the retina and ciliary body. Later, the blood test revealed positive HLA B27 and autoantibodies against lupus anticoagulant with mild elevation of C reactive protein. There were no signs for ankylosing spondylitis. Continued treatment and tapering of topical 1% prednisolone acetate for 4 weeks led to the complete resolution of the anterior uveitis. Conclusions We experienced HLA-B27 AAU with the feature of a very severe flare reaction. Conventional uveitis treatment was successful to acquire the complete resolution of the inflammation. |
| first_indexed | 2024-12-14T15:08:22Z |
| format | Article |
| id | doaj.art-f85bb32b84574531b4920b7967de3995 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-14T15:08:22Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-f85bb32b84574531b4920b7967de39952022-12-21T22:56:39ZengBMCBMC Ophthalmology1471-24152020-05-012011410.1186/s12886-020-01472-3A case of severe flare reaction observed in HLA B27 associated acute anterior uveitisJae-Ik Kim0Choul Yong Park1Department of Ophthalmology, Dongguk University, Ilsan HospitalDepartment of Ophthalmology, Dongguk University, Ilsan HospitalAbstract Background Anterior chamber flare reaction refers to the light reflection from the protein in aqueous humor. We report a case of very severe flare reaction observed in human leukocyte antigen (HLA)- B27 associated acute anterior uveitis (AAU). Case presentation An age 43 male patient visited the uveitis clinic complaining of decreased visual acuity in the right eye which developed 1 week before. The detailed ophthalmic examination revealed very severe flare reaction in the anterior chamber with diffuse conjunctival hyperemia in the right eye. Pupil margin and iris details were barely observable. Oral prednisolone 20 mg daily with topical 1% prednisolone acetate (Pred Forte, Allergan, CA) every 2 h and 1% topical cyclopentolate (Cyclogyl, Alcon, TX) three times daily were immediately prescribed. The next day, the flare reaction of the right eye decreased significantly and inflammatory cells in the anterior chamber were visible. Detailed fundus examination revealed no inflammatory signs on the retina and ciliary body. Later, the blood test revealed positive HLA B27 and autoantibodies against lupus anticoagulant with mild elevation of C reactive protein. There were no signs for ankylosing spondylitis. Continued treatment and tapering of topical 1% prednisolone acetate for 4 weeks led to the complete resolution of the anterior uveitis. Conclusions We experienced HLA-B27 AAU with the feature of a very severe flare reaction. Conventional uveitis treatment was successful to acquire the complete resolution of the inflammation.http://link.springer.com/article/10.1186/s12886-020-01472-3FlareHLA-B27Acute uveitisAAUImmune |
| spellingShingle | Jae-Ik Kim Choul Yong Park A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis BMC Ophthalmology Flare HLA-B27 Acute uveitis AAU Immune |
| title | A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis |
| title_full | A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis |
| title_fullStr | A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis |
| title_full_unstemmed | A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis |
| title_short | A case of severe flare reaction observed in HLA B27 associated acute anterior uveitis |
| title_sort | case of severe flare reaction observed in hla b27 associated acute anterior uveitis |
| topic | Flare HLA-B27 Acute uveitis AAU Immune |
| url | http://link.springer.com/article/10.1186/s12886-020-01472-3 |
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