Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases
The gastrointestinal (GI) tract is the largest reservoir of microbiota in the human body; however, it is still challenging to estimate the distribution and life patterns of microbes. Biofilm, as the predominant form in the microbial ecosystem, serves ideally to connect intestinal flora, molecules, a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1151552/full |
| _version_ | 1797847805197287424 |
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| author | Yumeng Wang Shixi Xu Qiurong He Kun Sun Xiaowan Wang Xiaorui Zhang Yuqing Li Jumei Zeng |
| author_facet | Yumeng Wang Shixi Xu Qiurong He Kun Sun Xiaowan Wang Xiaorui Zhang Yuqing Li Jumei Zeng |
| author_sort | Yumeng Wang |
| collection | DOAJ |
| description | The gastrointestinal (GI) tract is the largest reservoir of microbiota in the human body; however, it is still challenging to estimate the distribution and life patterns of microbes. Biofilm, as the predominant form in the microbial ecosystem, serves ideally to connect intestinal flora, molecules, and host mucosa cells. It gives bacteria the capacity to inhabit ecological niches, communicate with host cells, and withstand environmental stresses. This study intends to evaluate the connection between GI tract biofilms and chronic mucosa diseases such as chronic gastritis, inflammatory bowel disease, and colorectal cancer. In each disease, we summarize the representative biofilm makers including Helicobacter pylori, adherent-invasive Escherichia coli, Bacteroides fragilis, and Fusobacterium nucleatum. We address biofilm’s role in causing inflammation and the pro-carcinogenic stage in addition to discussing the typical resistance, persistence, and recurrence mechanisms seen in vitro. Biofilms may serve as a new biomarker for endoscopic and pathologic detection of gastrointestinal disease and suppression, which may be a useful addition to the present therapy strategy. |
| first_indexed | 2024-04-09T18:17:05Z |
| format | Article |
| id | doaj.art-f85be0c76f514e9d9980dfe631501f83 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-09T18:17:05Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f85be0c76f514e9d9980dfe631501f832023-04-13T04:22:57ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2023-04-011410.3389/fmicb.2023.11515521151552Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseasesYumeng Wang0Shixi Xu1Qiurong He2Kun Sun3Xiaowan Wang4Xiaorui Zhang5Yuqing Li6Jumei Zeng7West China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaState Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, ChinaWest China-PUMC C.C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, ChinaThe gastrointestinal (GI) tract is the largest reservoir of microbiota in the human body; however, it is still challenging to estimate the distribution and life patterns of microbes. Biofilm, as the predominant form in the microbial ecosystem, serves ideally to connect intestinal flora, molecules, and host mucosa cells. It gives bacteria the capacity to inhabit ecological niches, communicate with host cells, and withstand environmental stresses. This study intends to evaluate the connection between GI tract biofilms and chronic mucosa diseases such as chronic gastritis, inflammatory bowel disease, and colorectal cancer. In each disease, we summarize the representative biofilm makers including Helicobacter pylori, adherent-invasive Escherichia coli, Bacteroides fragilis, and Fusobacterium nucleatum. We address biofilm’s role in causing inflammation and the pro-carcinogenic stage in addition to discussing the typical resistance, persistence, and recurrence mechanisms seen in vitro. Biofilms may serve as a new biomarker for endoscopic and pathologic detection of gastrointestinal disease and suppression, which may be a useful addition to the present therapy strategy.https://www.frontiersin.org/articles/10.3389/fmicb.2023.1151552/fullbiofilmgastrointestinal tractmucosa diseasemicrobiotacrosstalk |
| spellingShingle | Yumeng Wang Shixi Xu Qiurong He Kun Sun Xiaowan Wang Xiaorui Zhang Yuqing Li Jumei Zeng Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases Frontiers in Microbiology biofilm gastrointestinal tract mucosa disease microbiota crosstalk |
| title | Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases |
| title_full | Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases |
| title_fullStr | Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases |
| title_full_unstemmed | Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases |
| title_short | Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases |
| title_sort | crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases |
| topic | biofilm gastrointestinal tract mucosa disease microbiota crosstalk |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2023.1151552/full |
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