Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks
Hippocampal firing is organized in theta sequences controlled by internal memory processes and by external sensory cues, but how these computations are coordinated is not fully understood. Although theta activity is commonly studied as a unique coherent oscillation, it is the result of complex inter...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2020-07-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/57313 |
| _version_ | 1818019912433532928 |
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| author | Víctor J López-Madrona Elena Pérez-Montoyo Efrén Álvarez-Salvado David Moratal Oscar Herreras Ernesto Pereda Claudio R Mirasso Santiago Canals |
| author_facet | Víctor J López-Madrona Elena Pérez-Montoyo Efrén Álvarez-Salvado David Moratal Oscar Herreras Ernesto Pereda Claudio R Mirasso Santiago Canals |
| author_sort | Víctor J López-Madrona |
| collection | DOAJ |
| description | Hippocampal firing is organized in theta sequences controlled by internal memory processes and by external sensory cues, but how these computations are coordinated is not fully understood. Although theta activity is commonly studied as a unique coherent oscillation, it is the result of complex interactions between different rhythm generators. Here, by separating hippocampal theta activity in three different current generators, we found epochs with variable theta frequency and phase coupling, suggesting flexible interactions between theta generators. We found that epochs of highly synchronized theta rhythmicity preferentially occurred during behavioral tasks requiring coordination between internal memory representations and incoming sensory information. In addition, we found that gamma oscillations were associated with specific theta generators and the strength of theta-gamma coupling predicted the synchronization between theta generators. We propose a mechanism for segregating or integrating hippocampal computations based on the flexible coordination of different theta frameworks to accommodate the cognitive needs. |
| first_indexed | 2024-04-14T07:58:07Z |
| format | Article |
| id | doaj.art-f85c0e6e1758488b9cfb3b86bcc0383e |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:58:07Z |
| publishDate | 2020-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-f85c0e6e1758488b9cfb3b86bcc0383e2022-12-22T02:04:58ZengeLife Sciences Publications LtdeLife2050-084X2020-07-01910.7554/eLife.57313Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasksVíctor J López-Madrona0https://orcid.org/0000-0001-8234-7160Elena Pérez-Montoyo1Efrén Álvarez-Salvado2David Moratal3Oscar Herreras4https://orcid.org/0000-0002-8210-3710Ernesto Pereda5Claudio R Mirasso6https://orcid.org/0000-0003-2980-7038Santiago Canals7https://orcid.org/0000-0003-2175-8139Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, San Juan de Alicante, SpainInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, San Juan de Alicante, SpainInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, San Juan de Alicante, SpainCentro de Biomateriales e Ingeniería Tisular, Universitat Politècnica de València, Valencia, SpainInstituto Cajal, Consejo Superior de Investigaciones Científicas, Madrid, SpainDepartamento de Ingeniería Industrial & IUNE, Escuela Superior de Ingeniería y Tecnología, Universidad de La Laguna, La Laguna, Spain; Laboratory of Cognitive and Computational Neuroscience, Center for Biomedical Technology, Madrid, SpainInstituto de Física Interdisciplinar y Sistemas Complejos, IFISC (CSIC-UIB), Campus Universitat de les Illes Balears, Palma de Mallorca, SpainInstituto de Neurociencias, Consejo Superior de Investigaciones Científicas, Universidad Miguel Hernández, San Juan de Alicante, SpainHippocampal firing is organized in theta sequences controlled by internal memory processes and by external sensory cues, but how these computations are coordinated is not fully understood. Although theta activity is commonly studied as a unique coherent oscillation, it is the result of complex interactions between different rhythm generators. Here, by separating hippocampal theta activity in three different current generators, we found epochs with variable theta frequency and phase coupling, suggesting flexible interactions between theta generators. We found that epochs of highly synchronized theta rhythmicity preferentially occurred during behavioral tasks requiring coordination between internal memory representations and incoming sensory information. In addition, we found that gamma oscillations were associated with specific theta generators and the strength of theta-gamma coupling predicted the synchronization between theta generators. We propose a mechanism for segregating or integrating hippocampal computations based on the flexible coordination of different theta frameworks to accommodate the cognitive needs.https://elifesciences.org/articles/57313hippocampusthetagammacross-frequency couplinglearninginformation transmission |
| spellingShingle | Víctor J López-Madrona Elena Pérez-Montoyo Efrén Álvarez-Salvado David Moratal Oscar Herreras Ernesto Pereda Claudio R Mirasso Santiago Canals Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks eLife hippocampus theta gamma cross-frequency coupling learning information transmission |
| title | Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks |
| title_full | Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks |
| title_fullStr | Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks |
| title_full_unstemmed | Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks |
| title_short | Different theta frameworks coexist in the rat hippocampus and are coordinated during memory-guided and novelty tasks |
| title_sort | different theta frameworks coexist in the rat hippocampus and are coordinated during memory guided and novelty tasks |
| topic | hippocampus theta gamma cross-frequency coupling learning information transmission |
| url | https://elifesciences.org/articles/57313 |
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