The Impact of Comprehensive Genomic Profiling (CGP) on the Decision-Making Process in the Treatment of ALK-Rearranged Advanced Non-Small Cell Lung Cancer (aNSCLC) After Failure of 2nd/3rd-Generation ALK Tyrosine Kinase Inhibitors (TKIs)

The Impact of Comprehensive Genomic Profiling (CGP) on the Decision-Making Process in the Treatment of ALK-Rearranged Advanced Non-Small Cell Lung Cancer (aNSCLC) After Failure of 2nd/3rd-Generation ALK Tyrosine Kinase Inhibitors (TKIs)

BackgroundThe use of CGP in guiding treatment decisions in aNSCLC with acquired resistance to ALK TKIs is questionable.MethodsWe prospectively assessed the impact of CGP on the decision-making process in ALK-rearranged aNSCLC patients following progression on 2nd/3rd-generation ALK TKIs. Physician’s...

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Bibliographic Details
Main Authors: Ari Raphael, Amir Onn, Liran Holtzman, Julia Dudnik, Damien Urban, Waleed Kian, Aharon Y. Cohen, Mor Moskovitz, Alona Zer, Jair Bar, Natalie Maimon Rabinovich, Shirly Grynberg, Cecilie Oedegaard, Abed Agbarya, Nir Peled, Tzippy Shochat, Elizabeth Dudnik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
comprehensive genomic profiling
next-generation sequencing
ALK
failure of ALK TKI
acquired resistance
decision impact
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.874712/full

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