Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary care center
Background: Thyroid disorders are the most common cause of endocrine dysfunction among women of childbearing age. It is well-established that hypothyroid dysfunction can have significant adverse effects on pregnancy and fetal development. This study aimed to determine the prevalence of thyroid disor...
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| Format: | Article |
| Language: | English |
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Golestan University of Medical Sciences
2023-11-01
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| Series: | Medical Laboratory Journal |
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| Online Access: | http://mlj.goums.ac.ir/article-1-1492-en.pdf |
| _version_ | 1797220439767908352 |
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| author | Thivyah Prabha Rasheed Khan Shruthi CN Rathi Priya |
| author_facet | Thivyah Prabha Rasheed Khan Shruthi CN Rathi Priya |
| author_sort | Thivyah Prabha |
| collection | DOAJ |
| description | Background: Thyroid disorders are the most common cause of endocrine dysfunction among women of childbearing age. It is well-established that hypothyroid dysfunction can have significant adverse effects on pregnancy and fetal development. This study aimed to determine the prevalence of thyroid disorders among antenatal women and assess the maternal and fetal outcomes in pregnant women with hypothyroid disorders.
Methods: This prospective study was conducted in the antenatal clinic of the Department of Obstetrics and Gynaecology in association with the Biochemistry Department. After obtaining written informed consent, antenatal women aged 18-40 years were included in this study, regardless of their gestational period. Venous blood samples were collected from the antecubital vein, and thyrotropin, free triiodothyronine (free T3), and free thyroxine (free T4) levels were measured. Hypothyroid antenatal women were monitored throughout their pregnancies to evaluate maternal and fetal outcomes.
Results: Among the participants in this study, 149 antenatal women had thyroid disorders, with a prevalence rate of 12.6%. Subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism were observed in 6.9%, 3.2%, 1.8%, and 0.7% of cases, respectively. Maternal complications included oligohydramnios (5.8%), preeclampsia (13.3%), and preterm delivery (5%), while fetal complications included low birth weight (20.8%), hyperbilirubinemia (9.1%), and neonatal intensive care unit (NICU) admissions (13.3%).
Conclusion: A high prevalence (12.6%) of thyroid disorders, particularly hypothyroidism (10.1%), among pregnant women, emphasizing the importance of routine thyroid testing for all antenatal individuals. |
| first_indexed | 2024-04-24T12:49:34Z |
| format | Article |
| id | doaj.art-f85ce8e5c3f94492a480399d70c445fc |
| institution | Directory Open Access Journal |
| issn | 2538-4449 |
| language | English |
| last_indexed | 2024-04-24T12:49:34Z |
| publishDate | 2023-11-01 |
| publisher | Golestan University of Medical Sciences |
| record_format | Article |
| series | Medical Laboratory Journal |
| spelling | doaj.art-f85ce8e5c3f94492a480399d70c445fc2024-04-06T09:52:07ZengGolestan University of Medical SciencesMedical Laboratory Journal2538-44492023-11-0117647Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary care centerThivyah Prabha0Rasheed Khan1Shruthi CN2Rathi Priya3 St.Peter’s Medical College Hospital and Research Institute, Hosur, Tamil Nadu, India Srinivasan Medical College and Hospital, Dhanalakshmi Srinivasan University, Tiruchirapalli, Tamil Nadu, India MVJ Medical College and Research Institute, Karnataka, India Eastpoint Medical College Hospital and Research Institute, Karnataka, India Background: Thyroid disorders are the most common cause of endocrine dysfunction among women of childbearing age. It is well-established that hypothyroid dysfunction can have significant adverse effects on pregnancy and fetal development. This study aimed to determine the prevalence of thyroid disorders among antenatal women and assess the maternal and fetal outcomes in pregnant women with hypothyroid disorders. Methods: This prospective study was conducted in the antenatal clinic of the Department of Obstetrics and Gynaecology in association with the Biochemistry Department. After obtaining written informed consent, antenatal women aged 18-40 years were included in this study, regardless of their gestational period. Venous blood samples were collected from the antecubital vein, and thyrotropin, free triiodothyronine (free T3), and free thyroxine (free T4) levels were measured. Hypothyroid antenatal women were monitored throughout their pregnancies to evaluate maternal and fetal outcomes. Results: Among the participants in this study, 149 antenatal women had thyroid disorders, with a prevalence rate of 12.6%. Subclinical hypothyroidism, overt hypothyroidism, subclinical hyperthyroidism, and overt hyperthyroidism were observed in 6.9%, 3.2%, 1.8%, and 0.7% of cases, respectively. Maternal complications included oligohydramnios (5.8%), preeclampsia (13.3%), and preterm delivery (5%), while fetal complications included low birth weight (20.8%), hyperbilirubinemia (9.1%), and neonatal intensive care unit (NICU) admissions (13.3%). Conclusion: A high prevalence (12.6%) of thyroid disorders, particularly hypothyroidism (10.1%), among pregnant women, emphasizing the importance of routine thyroid testing for all antenatal individuals.http://mlj.goums.ac.ir/article-1-1492-en.pdfhypothyroidismpregnancypre - eclampsiaabortioninducedbody weight |
| spellingShingle | Thivyah Prabha Rasheed Khan Shruthi CN Rathi Priya Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary care center Medical Laboratory Journal hypothyroidism pregnancy pre - eclampsia abortion induced body weight |
| title | Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary
care center |
| title_full | Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary
care center |
| title_fullStr | Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary
care center |
| title_full_unstemmed | Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary
care center |
| title_short | Maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary
care center |
| title_sort | maternal and fetal outcomes among antenatal women with hypothyroid disorders in a tertiary care center |
| topic | hypothyroidism pregnancy pre - eclampsia abortion induced body weight |
| url | http://mlj.goums.ac.ir/article-1-1492-en.pdf |
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