Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest
ABSTRACT Human skeletal hemodynamics remain understudied. Neither assessments in weight‐bearing bones during walking nor following periods of immobility exist, despite knowledge of altered nutrient‐artery characteristics after short‐duration unloading in rodents. We studied 12 older adults (8 female...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | JBMR Plus |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jbm4.10756 |
| _version_ | 1797781828839407616 |
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| author | Eric T Hedge Laurence Vico Richard L Hughson Carmelo J Mastrandrea |
| author_facet | Eric T Hedge Laurence Vico Richard L Hughson Carmelo J Mastrandrea |
| author_sort | Eric T Hedge |
| collection | DOAJ |
| description | ABSTRACT Human skeletal hemodynamics remain understudied. Neither assessments in weight‐bearing bones during walking nor following periods of immobility exist, despite knowledge of altered nutrient‐artery characteristics after short‐duration unloading in rodents. We studied 12 older adults (8 females, aged 59 ± 3 years) who participated in ambulatory near‐infrared spectroscopy (NIRS) assessments of tibial hemodynamics before (PRE) and after (POST) 14 days of head‐down bed rest (HDBR), with most performing daily resistance and aerobic exercise countermeasures during HDBR. Continual simultaneous NIRS recordings were acquired over the proximal anteromedial tibial prominence of the right lower leg and ipsilateral lateral head of the gastrocnemius muscle during supine rest, walking, and standing. During 10 minutes of walking, desaturation kinetics in the tibia were slower (time to 95% nadir values 125.4 ± 56.8 s versus 55.0 ± 30.1 s, p = 0.0014). Tibial tissue saturation index (TSI) immediately fell (−9.9 ± 4.55) and did not completely recover by the end of 10 minutes of walking (−7.4 ± 6.7%, p = 0.027). Upon standing, total hemoglobin (tHb) kinetics were faster in the tibia (p < 0.0001), whereas HDBR resulted in faster oxygenated hemoglogin (O2Hb) kinetics in both tissues (p = 0.039). After the walk‐to‐stand transition, changes in O2Hb (p = 0.0022) and tHb (p = 0.0047) were attenuated in the tibia alone after bed rest. Comparisons of NIRS‐derived variables during ambulation and changes in posture revealed potentially deleterious adaptations of feed vessels after HDBR. We identify important and novel tibial hemodynamics in humans during ambulation before and after bed rest, necessitating further investigation. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. |
| first_indexed | 2024-03-13T00:02:29Z |
| format | Article |
| id | doaj.art-f85ece45f64d458cb55b443d1b7e0960 |
| institution | Directory Open Access Journal |
| issn | 2473-4039 |
| language | English |
| last_indexed | 2024-03-13T00:02:29Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | JBMR Plus |
| spelling | doaj.art-f85ece45f64d458cb55b443d1b7e09602023-07-13T08:16:43ZengWileyJBMR Plus2473-40392023-07-0177n/an/a10.1002/jbm4.10756Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed RestEric T Hedge0Laurence Vico1Richard L Hughson2Carmelo J Mastrandrea3Schlegel‐UW Research Institute for Aging Waterloo CanadaU1059 INSERM—SAINBIOSE (Santé Ingéniérie Biologie St‐Etienne) Campus Santé Innovation Université Jean Monnet Saint‐Priest‐en‐Jarez FranceSchlegel‐UW Research Institute for Aging Waterloo CanadaSchlegel‐UW Research Institute for Aging Waterloo CanadaABSTRACT Human skeletal hemodynamics remain understudied. Neither assessments in weight‐bearing bones during walking nor following periods of immobility exist, despite knowledge of altered nutrient‐artery characteristics after short‐duration unloading in rodents. We studied 12 older adults (8 females, aged 59 ± 3 years) who participated in ambulatory near‐infrared spectroscopy (NIRS) assessments of tibial hemodynamics before (PRE) and after (POST) 14 days of head‐down bed rest (HDBR), with most performing daily resistance and aerobic exercise countermeasures during HDBR. Continual simultaneous NIRS recordings were acquired over the proximal anteromedial tibial prominence of the right lower leg and ipsilateral lateral head of the gastrocnemius muscle during supine rest, walking, and standing. During 10 minutes of walking, desaturation kinetics in the tibia were slower (time to 95% nadir values 125.4 ± 56.8 s versus 55.0 ± 30.1 s, p = 0.0014). Tibial tissue saturation index (TSI) immediately fell (−9.9 ± 4.55) and did not completely recover by the end of 10 minutes of walking (−7.4 ± 6.7%, p = 0.027). Upon standing, total hemoglobin (tHb) kinetics were faster in the tibia (p < 0.0001), whereas HDBR resulted in faster oxygenated hemoglogin (O2Hb) kinetics in both tissues (p = 0.039). After the walk‐to‐stand transition, changes in O2Hb (p = 0.0022) and tHb (p = 0.0047) were attenuated in the tibia alone after bed rest. Comparisons of NIRS‐derived variables during ambulation and changes in posture revealed potentially deleterious adaptations of feed vessels after HDBR. We identify important and novel tibial hemodynamics in humans during ambulation before and after bed rest, necessitating further investigation. © 2023 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.https://doi.org/10.1002/jbm4.10756HEAD‐DOWN BED RESTNEAR INFRARED SPECTROSCOPY (NIRS)SKELETAL VASCULAR SUPPLYTIBIAL HEMODYNAMICS |
| spellingShingle | Eric T Hedge Laurence Vico Richard L Hughson Carmelo J Mastrandrea Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest JBMR Plus HEAD‐DOWN BED REST NEAR INFRARED SPECTROSCOPY (NIRS) SKELETAL VASCULAR SUPPLY TIBIAL HEMODYNAMICS |
| title | Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest |
| title_full | Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest |
| title_fullStr | Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest |
| title_full_unstemmed | Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest |
| title_short | Effects of Posture and Walking on Tibial Vascular Hemodynamics Before and After 14 Days of Head‐Down Bed Rest |
| title_sort | effects of posture and walking on tibial vascular hemodynamics before and after 14 days of head down bed rest |
| topic | HEAD‐DOWN BED REST NEAR INFRARED SPECTROSCOPY (NIRS) SKELETAL VASCULAR SUPPLY TIBIAL HEMODYNAMICS |
| url | https://doi.org/10.1002/jbm4.10756 |
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