Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals
Abstract Phytochemicals present in detox juices and probiotics have demonstrated protective effects on cardiovascular risk factors. The consumption of these products alone modulate metabolic mechanisms and biomarkers. However, the effects of the combination of detox juice and probiotics have not yet...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2023-01-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100884&tlng=en |
| _version_ | 1797951348443971584 |
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| author | Eduardo Ottobelli Chielle Daniele Dalla Vecchia Eliandra Mirei Rossi Ana Paula Ottobelli Chielle Beatriz da Silva Rosa Bonadiman Filomena Marafon Margarete Dulce Bagatini |
| author_facet | Eduardo Ottobelli Chielle Daniele Dalla Vecchia Eliandra Mirei Rossi Ana Paula Ottobelli Chielle Beatriz da Silva Rosa Bonadiman Filomena Marafon Margarete Dulce Bagatini |
| author_sort | Eduardo Ottobelli Chielle |
| collection | DOAJ |
| description | Abstract Phytochemicals present in detox juices and probiotics have demonstrated protective effects on cardiovascular risk factors. The consumption of these products alone modulate metabolic mechanisms and biomarkers. However, the effects of the combination of detox juice and probiotics have not yet been evaluated on atherogenic parameters. A randomized controlled study was carried out with 40 healthy volunteers (20 men and 20 women), aged between 18 and 50 years old. The volunteers ingested 200mL of juice for 30 days. Before and after supplementation, the anthropometric and lipid profiles and plasma concentrations of TBARS, Myeloperoxidase, Glutathione, Protein and non-protein Thiols and Vitamin C were analyzed. A reduction in LDL-c (p=0.05), triglycerides (p=0.05) and a significant increase in HDL-c (p=0.002) was observed. There was a significant decrease in the concentrations of TBARS (p=0.01), myeloperoxidases (p=0.02) and a significant increase in the Vitamin C and GSH (p=0.01). There wasn`t improvement in anthropometric parameters and total cholesterol. The findings highlight that supplementation with probiotic detox juice improves the lipid and antioxidant profile, suggesting a possible positive effect in reducing the risk of cardiovascular disease in healthy volunteers. Nevertheless, more robust researches with a prolonged treatment period should be conducted. |
| first_indexed | 2024-04-10T22:29:09Z |
| format | Article |
| id | doaj.art-f85ef704bf37418cb7aa92152cfb575e |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-04-10T22:29:09Z |
| publishDate | 2023-01-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-f85ef704bf37418cb7aa92152cfb575e2023-01-17T07:34:51ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902023-01-015810.1590/s2175-97902022e20581Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individualsEduardo Ottobelli Chiellehttps://orcid.org/0000-0003-3566-1258Daniele Dalla Vecchiahttps://orcid.org/0000-0002-3190-6812Eliandra Mirei Rossihttps://orcid.org/0000-0001-6270-9953Ana Paula Ottobelli Chiellehttps://orcid.org/0000-0002-2453-335XBeatriz da Silva Rosa Bonadimanhttps://orcid.org/0000-0002-1968-0320Filomena Marafonhttps://orcid.org/0000-0001-9167-0146Margarete Dulce Bagatinihttps://orcid.org/0000-0001-9263-4980Abstract Phytochemicals present in detox juices and probiotics have demonstrated protective effects on cardiovascular risk factors. The consumption of these products alone modulate metabolic mechanisms and biomarkers. However, the effects of the combination of detox juice and probiotics have not yet been evaluated on atherogenic parameters. A randomized controlled study was carried out with 40 healthy volunteers (20 men and 20 women), aged between 18 and 50 years old. The volunteers ingested 200mL of juice for 30 days. Before and after supplementation, the anthropometric and lipid profiles and plasma concentrations of TBARS, Myeloperoxidase, Glutathione, Protein and non-protein Thiols and Vitamin C were analyzed. A reduction in LDL-c (p=0.05), triglycerides (p=0.05) and a significant increase in HDL-c (p=0.002) was observed. There was a significant decrease in the concentrations of TBARS (p=0.01), myeloperoxidases (p=0.02) and a significant increase in the Vitamin C and GSH (p=0.01). There wasn`t improvement in anthropometric parameters and total cholesterol. The findings highlight that supplementation with probiotic detox juice improves the lipid and antioxidant profile, suggesting a possible positive effect in reducing the risk of cardiovascular disease in healthy volunteers. Nevertheless, more robust researches with a prolonged treatment period should be conducted.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100884&tlng=enProbioticsDetox juiceOxidative stressCardiovascular diseases |
| spellingShingle | Eduardo Ottobelli Chielle Daniele Dalla Vecchia Eliandra Mirei Rossi Ana Paula Ottobelli Chielle Beatriz da Silva Rosa Bonadiman Filomena Marafon Margarete Dulce Bagatini Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals Brazilian Journal of Pharmaceutical Sciences Probiotics Detox juice Oxidative stress Cardiovascular diseases |
| title | Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals |
| title_full | Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals |
| title_fullStr | Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals |
| title_full_unstemmed | Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals |
| title_short | Supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals |
| title_sort | supplementation with detox juice added with probiotic improves atherogenic parameters in healthy individuals |
| topic | Probiotics Detox juice Oxidative stress Cardiovascular diseases |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502022000100884&tlng=en |
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