Visualizing the dynamics of histone variants in the S-phase nucleus
Abstract Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstructio...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-10-01
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| Series: | Genome Biology |
| Online Access: | http://link.springer.com/article/10.1186/s13059-018-1556-4 |
| _version_ | 1819107913967337472 |
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| author | Stella Maxouri Stavros Taraviras Zoi Lygerou |
| author_facet | Stella Maxouri Stavros Taraviras Zoi Lygerou |
| author_sort | Stella Maxouri |
| collection | DOAJ |
| description | Abstract Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstruction microscopy (STORM) to obtain a high-resolution view of the spatial distribution of H3 histone variants in the nucleus and related this to the timing of DNA replication. |
| first_indexed | 2024-12-22T03:01:36Z |
| format | Article |
| id | doaj.art-f85fcd0df6374665a412fdbc8c0c02ee |
| institution | Directory Open Access Journal |
| issn | 1474-760X |
| language | English |
| last_indexed | 2024-12-22T03:01:36Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Genome Biology |
| spelling | doaj.art-f85fcd0df6374665a412fdbc8c0c02ee2022-12-21T18:41:10ZengBMCGenome Biology1474-760X2018-10-011911310.1186/s13059-018-1556-4Visualizing the dynamics of histone variants in the S-phase nucleusStella Maxouri0Stavros Taraviras1Zoi Lygerou2Laboratory of Biology, School of Medicine, University of PatrasLaboratory of Physiology, School of Medicine, University of PatrasLaboratory of Biology, School of Medicine, University of PatrasAbstract Histone variants constitute a fundamental feature of the epigenome. However, their dynamics during normal and challenged DNA replication and their distribution in the three-dimensional space of the nucleus remain poorly characterized. A recent study employed stochastic optical reconstruction microscopy (STORM) to obtain a high-resolution view of the spatial distribution of H3 histone variants in the nucleus and related this to the timing of DNA replication.http://link.springer.com/article/10.1186/s13059-018-1556-4 |
| spellingShingle | Stella Maxouri Stavros Taraviras Zoi Lygerou Visualizing the dynamics of histone variants in the S-phase nucleus Genome Biology |
| title | Visualizing the dynamics of histone variants in the S-phase nucleus |
| title_full | Visualizing the dynamics of histone variants in the S-phase nucleus |
| title_fullStr | Visualizing the dynamics of histone variants in the S-phase nucleus |
| title_full_unstemmed | Visualizing the dynamics of histone variants in the S-phase nucleus |
| title_short | Visualizing the dynamics of histone variants in the S-phase nucleus |
| title_sort | visualizing the dynamics of histone variants in the s phase nucleus |
| url | http://link.springer.com/article/10.1186/s13059-018-1556-4 |
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