Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents
Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity ass...
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| Format: | Article |
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KeAi Communications Co., Ltd.
2017-09-01
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| Series: | Genes and Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304217300375 |
| _version_ | 1797727897562120192 |
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| author | Samar Samir Abdelmajed Mohamed Youssef Moushira Erfan Zaki Naglaa Abu-Mandil Hassan Somaia Ismail |
| author_facet | Samar Samir Abdelmajed Mohamed Youssef Moushira Erfan Zaki Naglaa Abu-Mandil Hassan Somaia Ismail |
| author_sort | Samar Samir Abdelmajed |
| collection | DOAJ |
| description | Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated (FTO) gene and obesity in adults and children in different ethnic groups. In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. The current study showed that there were no significant differences (P > 0.05) between the cases and controls in both variants of rs17817449 and rs9939609 polymorphisms.
However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL. In Current Study although the two variants (rs9939609 and rs17817449) didn't show an association with obesity, but there was a correlation between the lipid profile and these two variants. |
| first_indexed | 2024-03-12T11:06:03Z |
| format | Article |
| id | doaj.art-f860639e050141778ca144ffbd8728c1 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T11:06:03Z |
| publishDate | 2017-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-f860639e050141778ca144ffbd8728c12023-09-02T03:57:53ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422017-09-014317017510.1016/j.gendis.2017.06.002Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescentsSamar Samir Abdelmajed0Mohamed Youssef1Moushira Erfan Zaki2Naglaa Abu-Mandil Hassan3Somaia Ismail4October University for Modern Sciences and Arts (MSA), Giza, EgyptOrganic chemistry Department, Faculty of science, Cairo University, EgyptBiological Anthropology Department, Medical Research Division, National Research Centre, EgyptBiological Anthropology Department, Medical Research Division, National Research Centre, EgyptMedical Molecular Genetics Department, Human Genetics and Genome Research Division, National Research Centre, Giza, EgyptObesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated (FTO) gene and obesity in adults and children in different ethnic groups. In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. The current study showed that there were no significant differences (P > 0.05) between the cases and controls in both variants of rs17817449 and rs9939609 polymorphisms. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL. In Current Study although the two variants (rs9939609 and rs17817449) didn't show an association with obesity, but there was a correlation between the lipid profile and these two variants.http://www.sciencedirect.com/science/article/pii/S2352304217300375ChildrenEgyptiansFat mass and obesity associated gene (FTO)ObesityVariants |
| spellingShingle | Samar Samir Abdelmajed Mohamed Youssef Moushira Erfan Zaki Naglaa Abu-Mandil Hassan Somaia Ismail Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents Genes and Diseases Children Egyptians Fat mass and obesity associated gene (FTO) Obesity Variants |
| title | Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents |
| title_full | Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents |
| title_fullStr | Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents |
| title_full_unstemmed | Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents |
| title_short | Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents |
| title_sort | association analysis of fto gene polymorphisms and obesity risk among egyptian children and adolescents |
| topic | Children Egyptians Fat mass and obesity associated gene (FTO) Obesity Variants |
| url | http://www.sciencedirect.com/science/article/pii/S2352304217300375 |
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