Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis
Abstract Malignancy-related hypercalcemia is a leading cause of hypercalcemia among hospitalized patients that carries poor prognosis. Parathyroid carcinoma is a rare form of primary hyperparathyroidism that may be associated with PTH dependent hypercalcemia. Severe hypercalcemia is life-threatening...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-06-01
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| Series: | European Journal of Medical Research |
| Online Access: | https://doi.org/10.1186/s40001-022-00715-x |
| _version_ | 1811251512882495488 |
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| author | Marc Scheen Grzegorz Nowak Bienvenido Sanchez Daniel Teta |
| author_facet | Marc Scheen Grzegorz Nowak Bienvenido Sanchez Daniel Teta |
| author_sort | Marc Scheen |
| collection | DOAJ |
| description | Abstract Malignancy-related hypercalcemia is a leading cause of hypercalcemia among hospitalized patients that carries poor prognosis. Parathyroid carcinoma is a rare form of primary hyperparathyroidism that may be associated with PTH dependent hypercalcemia. Severe hypercalcemia is life-threatening and may require management in an intensive care unit by means of medical therapy consisting of volume expansion, loop diuretics, cinacalcet, calcitonin and bisphosphonates. Renal replacement therapy such as intermittent hemodialysis has been successfully used among patients with severe hypercalcemia who become refractory to medical treatment. However, little data are available for cases of severe refractory hypercalcemia that fail to respond to both optimal medical therapy and hemodialysis. Our present case illustrates the successful use of continuous veno-venous hemodiafiltration (CVVHDF) with calcium-free dialysate calcium and markedly increased dialysate flow rate, to restore normal calcemia in a patient with metastatic parathyroid carcinoma with severe refractory hypercalcemia. |
| first_indexed | 2024-04-12T16:20:33Z |
| format | Article |
| id | doaj.art-f86180a353644ce2866798a479205dfb |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-04-12T16:20:33Z |
| publishDate | 2022-06-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-f86180a353644ce2866798a479205dfb2022-12-22T03:25:34ZengBMCEuropean Journal of Medical Research2047-783X2022-06-012711410.1186/s40001-022-00715-xFine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysisMarc Scheen0Grzegorz Nowak1Bienvenido Sanchez2Daniel Teta3Service of Nephrology, Hôpital du ValaisService of Nephrology, Hôpital du ValaisService of Intensive Care Medicine, Hôpital du ValaisService of Nephrology, Hôpital du ValaisAbstract Malignancy-related hypercalcemia is a leading cause of hypercalcemia among hospitalized patients that carries poor prognosis. Parathyroid carcinoma is a rare form of primary hyperparathyroidism that may be associated with PTH dependent hypercalcemia. Severe hypercalcemia is life-threatening and may require management in an intensive care unit by means of medical therapy consisting of volume expansion, loop diuretics, cinacalcet, calcitonin and bisphosphonates. Renal replacement therapy such as intermittent hemodialysis has been successfully used among patients with severe hypercalcemia who become refractory to medical treatment. However, little data are available for cases of severe refractory hypercalcemia that fail to respond to both optimal medical therapy and hemodialysis. Our present case illustrates the successful use of continuous veno-venous hemodiafiltration (CVVHDF) with calcium-free dialysate calcium and markedly increased dialysate flow rate, to restore normal calcemia in a patient with metastatic parathyroid carcinoma with severe refractory hypercalcemia.https://doi.org/10.1186/s40001-022-00715-x |
| spellingShingle | Marc Scheen Grzegorz Nowak Bienvenido Sanchez Daniel Teta Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis European Journal of Medical Research |
| title | Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis |
| title_full | Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis |
| title_fullStr | Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis |
| title_full_unstemmed | Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis |
| title_short | Fine-tuned continuous renal replacement therapy with calcium-free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis |
| title_sort | fine tuned continuous renal replacement therapy with calcium free dialysate to manage severe hypercalcemia refractory to medical and intermittent hemodialysis |
| url | https://doi.org/10.1186/s40001-022-00715-x |
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