Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives
This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-<i>e</i>][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[4,3-<i>b</i>][1,2,4]triazines and pyrazo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/17/3948 |
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| author | Zofia Bernat Anna Szymanowska Mateusz Kciuk Katarzyna Kotwica-Mojzych Mariusz Mojzych |
| author_facet | Zofia Bernat Anna Szymanowska Mateusz Kciuk Katarzyna Kotwica-Mojzych Mariusz Mojzych |
| author_sort | Zofia Bernat |
| collection | DOAJ |
| description | This review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-<i>e</i>][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[4,3-<i>b</i>][1,2,4]triazines and pyrazolo[4,3-<i>e</i>]tetrazolo[1,5-<i>b</i>][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy. |
| first_indexed | 2024-03-10T16:43:27Z |
| format | Article |
| id | doaj.art-f862bfc90f7046819323b39a094558ee |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T16:43:27Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f862bfc90f7046819323b39a094558ee2023-11-20T11:51:06ZengMDPI AGMolecules1420-30492020-08-012517394810.3390/molecules25173948Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine DerivativesZofia Bernat0Anna Szymanowska1Mateusz Kciuk2Katarzyna Kotwica-Mojzych3Mariusz Mojzych4Department of Chemistry, Siedlce University of Natural Sciences and Humanities, 3 Maja 54, 08-110 Siedlce, PolandDepartment of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-222 Bialystok, PolandDepartment of Molecular Biotechnology and Genetics, Laboratory of Cytogenetics, University of Lodz, Banacha 12/16, 90-237 Lodz, PolandDepartment of Histology, Embryology and Cytophysiology, Medical University of Lublin, Radziwiłłowska 11, (Collegium Medicum), 20-080 Lublin, PolandDepartment of Chemistry, Siedlce University of Natural Sciences and Humanities, 3 Maja 54, 08-110 Siedlce, PolandThis review focuses on the cytotoxic effect of new synthetic pyrazolo[4,3-<i>e</i>][1,2,4]triazine derivatives against different tumor cell lines. Some annulated pyrazolotriazines i.e., pyrazolo[4,3-<i>e</i>][1,2,4]triazolo[4,3-<i>b</i>][1,2,4]triazines and pyrazolo[4,3-<i>e</i>]tetrazolo[1,5-<i>b</i>][1,2,4]triazine demonstrated significant broad cytotoxic activity in micromolar range concentration, which could have excellent potential to be new candidate therapeutic agents in cancer chemotherapy.https://www.mdpi.com/1420-3049/25/17/3948pyrazolo[4,3-<i>e</i>][1,2,4]triazinesanticancer activitysulfonamides1,2,4-triazinefused tetrazole derivativesfluviols |
| spellingShingle | Zofia Bernat Anna Szymanowska Mateusz Kciuk Katarzyna Kotwica-Mojzych Mariusz Mojzych Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives Molecules pyrazolo[4,3-<i>e</i>][1,2,4]triazines anticancer activity sulfonamides 1,2,4-triazine fused tetrazole derivatives fluviols |
| title | Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives |
| title_full | Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives |
| title_fullStr | Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives |
| title_full_unstemmed | Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives |
| title_short | Review of the Synthesis and Anticancer Properties of Pyrazolo[4,3-<i>e</i>][1,2,4]triazine Derivatives |
| title_sort | review of the synthesis and anticancer properties of pyrazolo 4 3 i e i 1 2 4 triazine derivatives |
| topic | pyrazolo[4,3-<i>e</i>][1,2,4]triazines anticancer activity sulfonamides 1,2,4-triazine fused tetrazole derivatives fluviols |
| url | https://www.mdpi.com/1420-3049/25/17/3948 |
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