Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic
Abstract Background Tibial fractures are the most common fractures seen in adults and lead to the most nonunions. Osteogenesis imperfecta (OI) is characterized by increased bone fragility and higher risk of fractures. No studies have been published on the incidence of tibial fractures and nonunions...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-12-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-022-05966-7 |
| _version_ | 1811301847767449600 |
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| author | Simone Amber Munk Gerrit Jan Harsevoort Koert Gooijer Mireille Angélique Edens Antonius Adrianus Franken Guus Johannes Maria Janus |
| author_facet | Simone Amber Munk Gerrit Jan Harsevoort Koert Gooijer Mireille Angélique Edens Antonius Adrianus Franken Guus Johannes Maria Janus |
| author_sort | Simone Amber Munk |
| collection | DOAJ |
| description | Abstract Background Tibial fractures are the most common fractures seen in adults and lead to the most nonunions. Osteogenesis imperfecta (OI) is characterized by increased bone fragility and higher risk of fractures. No studies have been published on the incidence of tibial fractures and nonunions in adults with OI. This study aims to summarize the incidence of tibial fractures and nonunions in this population. Methods A retrospective, descriptive study. All medical charts of adult patients in the OI database of our OI expert clinic were analyzed for tibial fractures between 2008 and 2020. Tibial fracture incidence, nonunion rate, treatment modality and potential risk factors were determined. Results The database consisted of 402 patients, 34 of whom had suffered one or more tibial fractures, resulting in 42 fractures. The incidence of tibial fractures in adults with OI is 870 per 100,000 person-years. Two out of 42 fractures led to nonunion (5%). It was not possible to adjust for risk factors or type of treatment. Conclusion There is a higher incidence of tibial fractures in patients with OI, but a nonunion rate comparable to the general population. With only two nonunions it is not possible to draw conclusions on the influence of risk factors or treatment of tibial fractures on OI. |
| first_indexed | 2024-04-13T07:17:23Z |
| format | Article |
| id | doaj.art-f864245c60f14c22a8626d9e7757115a |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-13T07:17:23Z |
| publishDate | 2022-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-f864245c60f14c22a8626d9e7757115a2022-12-22T02:56:43ZengBMCBMC Musculoskeletal Disorders1471-24742022-12-012311610.1186/s12891-022-05966-7Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinicSimone Amber Munk0Gerrit Jan Harsevoort1Koert Gooijer2Mireille Angélique Edens3Antonius Adrianus Franken4Guus Johannes Maria Janus5Department of Orthopedic Surgery, IsalaDepartment of Orthopedic Surgery, IsalaDepartment of Orthopedic Surgery, IsalaEpidemiology Unit, Department Innovation and Science, IsalaDepartment of Internal MedicineDepartment of Orthopedic Surgery, IsalaAbstract Background Tibial fractures are the most common fractures seen in adults and lead to the most nonunions. Osteogenesis imperfecta (OI) is characterized by increased bone fragility and higher risk of fractures. No studies have been published on the incidence of tibial fractures and nonunions in adults with OI. This study aims to summarize the incidence of tibial fractures and nonunions in this population. Methods A retrospective, descriptive study. All medical charts of adult patients in the OI database of our OI expert clinic were analyzed for tibial fractures between 2008 and 2020. Tibial fracture incidence, nonunion rate, treatment modality and potential risk factors were determined. Results The database consisted of 402 patients, 34 of whom had suffered one or more tibial fractures, resulting in 42 fractures. The incidence of tibial fractures in adults with OI is 870 per 100,000 person-years. Two out of 42 fractures led to nonunion (5%). It was not possible to adjust for risk factors or type of treatment. Conclusion There is a higher incidence of tibial fractures in patients with OI, but a nonunion rate comparable to the general population. With only two nonunions it is not possible to draw conclusions on the influence of risk factors or treatment of tibial fractures on OI.https://doi.org/10.1186/s12891-022-05966-7Osteogenesis imperfectaTibial fractureNonunionAdult |
| spellingShingle | Simone Amber Munk Gerrit Jan Harsevoort Koert Gooijer Mireille Angélique Edens Antonius Adrianus Franken Guus Johannes Maria Janus Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic BMC Musculoskeletal Disorders Osteogenesis imperfecta Tibial fracture Nonunion Adult |
| title | Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic |
| title_full | Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic |
| title_fullStr | Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic |
| title_full_unstemmed | Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic |
| title_short | Incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta: a retrospective cohort study of 402 patients with 42 fractures at an expert clinic |
| title_sort | incidence and nonunion rates of tibial fractures in adults with osteogenesis imperfecta a retrospective cohort study of 402 patients with 42 fractures at an expert clinic |
| topic | Osteogenesis imperfecta Tibial fracture Nonunion Adult |
| url | https://doi.org/10.1186/s12891-022-05966-7 |
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