Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination

Urinary Metabolomic Profiling in Zucker Diabetic Fatty Rats with Type 2 Diabetes Mellitus Treated with Glimepiride, Metformin, and Their Combination

Type 2 diabetes mellitus (T2DM) is a high incidence metabolic disease. Glimepiride, metformin, and their combination are the most commonly used therapeutics for T2DM in the clinic, but little is known about the metabolic responses of these therapies. In this study, ultrahigh-pressure liquid chromato...

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Bibliographic Details
Main Authors: Yu Dong, Yi-Tao Chen, Yuan-Xiao Yang, Dan Shou, Chang-Yu Li
Format: Article
Language:English
Published: MDPI AG 2016-10-01
Series:Molecules
Subjects:
type 2 diabetes mellitus
Zucker diabetic fatty rats
metformin
glimepiride
combination
UHPLC/ESI-QTOF-MS
Online Access:http://www.mdpi.com/1420-3049/21/11/1446

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