Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer
Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution. The company of Kelch-like ECH-associated protei...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/12/3/735 |
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| author | Somayyeh Ghareghomi Faezeh Moosavi-Movahedi Luciano Saso Mehran Habibi-Rezaei Ali Khatibi Jun Hong Ali A. Moosavi-Movahedi |
| author_facet | Somayyeh Ghareghomi Faezeh Moosavi-Movahedi Luciano Saso Mehran Habibi-Rezaei Ali Khatibi Jun Hong Ali A. Moosavi-Movahedi |
| author_sort | Somayyeh Ghareghomi |
| collection | DOAJ |
| description | Oxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution. The company of Kelch-like ECH-associated protein 1 (Keap1) as a molecular sensing element of the oxidative and electrophilic stress and nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) as a master transcriptional regulator of the antioxidant response makes a master cytoprotective antioxidant pathway known as the Keap1/Nrf2 pathway. This pathway is considered a dual-edged sword with beneficial features for both normal and cancer cells by regulating the gene expression of the array of endogenous antioxidant enzymes. Heme oxygenase-1 (HO-1), a critical enzyme in toxic heme removal, is one of the clear state indicators for the duality of this pathway. Therefore, Nrf2/HO-1 axis targeting is known as a novel strategy for cancer treatment. In this review, the molecular mechanism of action of natural antioxidants on lung cancer cells has been investigated by relying on the Nrf2/HO-1 axis. |
| first_indexed | 2024-03-11T07:01:05Z |
| format | Article |
| id | doaj.art-f86495cbd40644649d25ecde43b9fa0d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T07:01:05Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-f86495cbd40644649d25ecde43b9fa0d2023-11-17T09:19:02ZengMDPI AGAntioxidants2076-39212023-03-0112373510.3390/antiox12030735Modulation of Nrf2/HO-1 by Natural Compounds in Lung CancerSomayyeh Ghareghomi0Faezeh Moosavi-Movahedi1Luciano Saso2Mehran Habibi-Rezaei3Ali Khatibi4Jun Hong5Ali A. Moosavi-Movahedi6Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, IranInstitute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, IranDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, 00185 Rome, ItalySchool of Biology, College of Science, University of Tehran, Tehran 1417466191, IranDepartment of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran 1993893973, IranSchool of Life Sciences, Henan University, Kaifeng 475000, ChinaInstitute of Biochemistry and Biophysics, University of Tehran, Tehran 1417466191, IranOxidative stresses (OSs) are considered a pivotal factor in creating various pathophysiological conditions. Cells have been able to move forward by modulating numerous signaling pathways to moderate the defects of these stresses during their evolution. The company of Kelch-like ECH-associated protein 1 (Keap1) as a molecular sensing element of the oxidative and electrophilic stress and nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) as a master transcriptional regulator of the antioxidant response makes a master cytoprotective antioxidant pathway known as the Keap1/Nrf2 pathway. This pathway is considered a dual-edged sword with beneficial features for both normal and cancer cells by regulating the gene expression of the array of endogenous antioxidant enzymes. Heme oxygenase-1 (HO-1), a critical enzyme in toxic heme removal, is one of the clear state indicators for the duality of this pathway. Therefore, Nrf2/HO-1 axis targeting is known as a novel strategy for cancer treatment. In this review, the molecular mechanism of action of natural antioxidants on lung cancer cells has been investigated by relying on the Nrf2/HO-1 axis.https://www.mdpi.com/2076-3921/12/3/735oxidative stressKeap/Nrf2 pathwayHeme oxygenase-1antioxidantslung cancer |
| spellingShingle | Somayyeh Ghareghomi Faezeh Moosavi-Movahedi Luciano Saso Mehran Habibi-Rezaei Ali Khatibi Jun Hong Ali A. Moosavi-Movahedi Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer Antioxidants oxidative stress Keap/Nrf2 pathway Heme oxygenase-1 antioxidants lung cancer |
| title | Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer |
| title_full | Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer |
| title_fullStr | Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer |
| title_full_unstemmed | Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer |
| title_short | Modulation of Nrf2/HO-1 by Natural Compounds in Lung Cancer |
| title_sort | modulation of nrf2 ho 1 by natural compounds in lung cancer |
| topic | oxidative stress Keap/Nrf2 pathway Heme oxygenase-1 antioxidants lung cancer |
| url | https://www.mdpi.com/2076-3921/12/3/735 |
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