Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand
Kitchawan Hengkrawit,1 Chidchanok Tangjade2 1Pediatric Infectious Disease Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, Nonthaburi, Thailand; 2Pediatrics Gastroenterology and Hepatology Unit, Department of Pediatrics, Panyananthaphikkhu Ch...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-11-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/factors-associated-with-multi-drug-resistant-non-typhoidal-salmonella--peer-reviewed-fulltext-article-IDR |
| _version_ | 1811233371346436096 |
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| author | Hengkrawit K Tangjade C |
| author_facet | Hengkrawit K Tangjade C |
| author_sort | Hengkrawit K |
| collection | DOAJ |
| description | Kitchawan Hengkrawit,1 Chidchanok Tangjade2 1Pediatric Infectious Disease Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, Nonthaburi, Thailand; 2Pediatrics Gastroenterology and Hepatology Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, Nonthaburi, ThailandCorrespondence: Chidchanok Tangjade, Pediatrics Gastroenterology and Hepatology Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, P.O. Box 222 Moo 1, Tiwanon Road, Pak Kret, Nonthaburi, 11120, Thailand, Tel +66 2 502 2345, Fax +66 2 502-2305, Email Chidchanok@g.swu.ac.th.comPurpose: Invasive non-typhoidal Salmonella disease, iNTS is a major global health concern, especially multi-drug resistant non-typhoidal Salmonella, MDR-NTS. Information about risk factors of MDR-NTS in the invasive disease patient group was limited. This study aimed to identify those risk factors.Methods: This retrospective study examined data from patients who had non-typhoidal Salmonella, NTS infection, from 10 hospitals between June 2011 and June 2020. The multivariate regression analysis included demographic data, clinical data, culture reports, and antimicrobial susceptibility.Results: A total of 166 patients were invasive salmonellosis. where the median age was 8.3 years (IQR 1.8– 79). 52% were the under-15-years-old group. Most of the patient data, 64.5% (107/166), was from a tertiary hospital. The majority of cases were bacteremia 95.7% (159/166). Serogroup C was the most common serogroup (39%). MDR-NTS was present in 68.8% (95% CI 7.17– 11.06) of patients. Univariate analysis showed that onset of illness > 3 days PTA (p=0.11), age over 60 years old (0.014), diabetic (p=0.002), or serogroup C infection (p=0.43) were significant factors for MDR-NTS infection. Multivariate analysis showed that the onset of symptoms more than 3 days before admission (p=0.001), and age over 60 years were significant factors. The patient who had white blood cells > 15,000 cells/uL (p< 0.001), a peak of fever ≥ 39 C° (p=001), and illness for more than 3 days before admission (p=0.035) were significantly related to invasive infection by multivariate analyses.Conclusion: The iNTS patients who were over 60 years old or had onset of illness more than 3 days before admission were associated with MDR-NTS infection. Therefore, the choice of antimicrobials selected must be appropriate for the local prevalence and epidemiology of MDR-NTS including clinical correlation.Keywords: risk factor, multi-drug resistance, non-typhoidal Salmonella, invasive infection, invasive non-typhoidal Salmonella disease |
| first_indexed | 2024-04-12T11:19:34Z |
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| id | doaj.art-f86c8403256f4ebabc48be2076b161bb |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-04-12T11:19:34Z |
| publishDate | 2022-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-f86c8403256f4ebabc48be2076b161bb2022-12-22T03:35:25ZengDove Medical PressInfection and Drug Resistance1178-69732022-11-01Volume 156563657679569Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, ThailandHengkrawit KTangjade CKitchawan Hengkrawit,1 Chidchanok Tangjade2 1Pediatric Infectious Disease Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, Nonthaburi, Thailand; 2Pediatrics Gastroenterology and Hepatology Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, Nonthaburi, ThailandCorrespondence: Chidchanok Tangjade, Pediatrics Gastroenterology and Hepatology Unit, Department of Pediatrics, Panyananthaphikkhu Chonprathan Medical Center, Srinakarinwirot University, P.O. Box 222 Moo 1, Tiwanon Road, Pak Kret, Nonthaburi, 11120, Thailand, Tel +66 2 502 2345, Fax +66 2 502-2305, Email Chidchanok@g.swu.ac.th.comPurpose: Invasive non-typhoidal Salmonella disease, iNTS is a major global health concern, especially multi-drug resistant non-typhoidal Salmonella, MDR-NTS. Information about risk factors of MDR-NTS in the invasive disease patient group was limited. This study aimed to identify those risk factors.Methods: This retrospective study examined data from patients who had non-typhoidal Salmonella, NTS infection, from 10 hospitals between June 2011 and June 2020. The multivariate regression analysis included demographic data, clinical data, culture reports, and antimicrobial susceptibility.Results: A total of 166 patients were invasive salmonellosis. where the median age was 8.3 years (IQR 1.8– 79). 52% were the under-15-years-old group. Most of the patient data, 64.5% (107/166), was from a tertiary hospital. The majority of cases were bacteremia 95.7% (159/166). Serogroup C was the most common serogroup (39%). MDR-NTS was present in 68.8% (95% CI 7.17– 11.06) of patients. Univariate analysis showed that onset of illness > 3 days PTA (p=0.11), age over 60 years old (0.014), diabetic (p=0.002), or serogroup C infection (p=0.43) were significant factors for MDR-NTS infection. Multivariate analysis showed that the onset of symptoms more than 3 days before admission (p=0.001), and age over 60 years were significant factors. The patient who had white blood cells > 15,000 cells/uL (p< 0.001), a peak of fever ≥ 39 C° (p=001), and illness for more than 3 days before admission (p=0.035) were significantly related to invasive infection by multivariate analyses.Conclusion: The iNTS patients who were over 60 years old or had onset of illness more than 3 days before admission were associated with MDR-NTS infection. Therefore, the choice of antimicrobials selected must be appropriate for the local prevalence and epidemiology of MDR-NTS including clinical correlation.Keywords: risk factor, multi-drug resistance, non-typhoidal Salmonella, invasive infection, invasive non-typhoidal Salmonella diseasehttps://www.dovepress.com/factors-associated-with-multi-drug-resistant-non-typhoidal-salmonella--peer-reviewed-fulltext-article-IDRrisk factormulti-drug resistancenon-typhoidal salmonellainvasive infectioninvasive non-typhoidal salmonella disease. |
| spellingShingle | Hengkrawit K Tangjade C Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand Infection and Drug Resistance risk factor multi-drug resistance non-typhoidal salmonella invasive infection invasive non-typhoidal salmonella disease. |
| title | Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand |
| title_full | Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand |
| title_fullStr | Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand |
| title_full_unstemmed | Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand |
| title_short | Factors Associated with Multi-Drug-Resistant Non-Typhoidal Salmonella in the Invasive Disease, Thailand |
| title_sort | factors associated with multi drug resistant non typhoidal salmonella in the invasive disease thailand |
| topic | risk factor multi-drug resistance non-typhoidal salmonella invasive infection invasive non-typhoidal salmonella disease. |
| url | https://www.dovepress.com/factors-associated-with-multi-drug-resistant-non-typhoidal-salmonella--peer-reviewed-fulltext-article-IDR |
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