Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study
Abstract Age at onset of epilepsy is an important predictor of deterioration in naming ability following epilepsy surgery. In 141 patients with left hemispheric epilepsy and language dominance who received epilepsy surgery at the Epilepsy Centre Erlangen, naming of objects (Boston naming test, BNT)...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40722-4 |
| _version_ | 1797453248844529664 |
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| author | Caroline Reindl Katrin Walther Anna-Lena Allgäuer Johannes D. Lang Tamara M. Welte Jenny Stritzelberger Stephanie Gollwitzer Michael Schwarz Regina Trollmann Dominik Madzar Michael Knott Arnd Doerfler Frank Seifert Karl Rössler Sebastian Brandner Stefan Rampp Stefan Schwab Hajo M. Hamer |
| author_facet | Caroline Reindl Katrin Walther Anna-Lena Allgäuer Johannes D. Lang Tamara M. Welte Jenny Stritzelberger Stephanie Gollwitzer Michael Schwarz Regina Trollmann Dominik Madzar Michael Knott Arnd Doerfler Frank Seifert Karl Rössler Sebastian Brandner Stefan Rampp Stefan Schwab Hajo M. Hamer |
| author_sort | Caroline Reindl |
| collection | DOAJ |
| description | Abstract Age at onset of epilepsy is an important predictor of deterioration in naming ability following epilepsy surgery. In 141 patients with left hemispheric epilepsy and language dominance who received epilepsy surgery at the Epilepsy Centre Erlangen, naming of objects (Boston naming test, BNT) was assessed preoperatively and 6 months postoperatively. Surgical lesions were plotted on postoperative MRI and normalized for statistical analysis using voxel-based lesion-symptom mapping (VBLSM). The correlation between lesion and presence of postoperative naming deterioration was examined varying the considered age range of epilepsy onsets. The VBLSM analysis showed that volumes of cortex areas in the left temporal lobe, which were associated with postoperative decline of naming, increased with each year of later epilepsy onset. In patients with later onset, an increasing left posterior temporobasal area was significantly associated with a postoperative deficit when included in the resection. For late epilepsy onset, the temporomesial expansion also included the left hippocampus. The results underline that early onset of epilepsy is a good prognostic factor for unchanged postoperative naming ability following epilepsy surgery. For later age of epilepsy onset, the extent of the area at risk of postoperative naming deficit at 6 months after surgery included an increasing left temporobasal area which finally also comprised the hippocampus. |
| first_indexed | 2024-03-09T15:20:04Z |
| format | Article |
| id | doaj.art-f86d0481e8714576a3fa6c4278e02840 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:20:04Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f86d0481e8714576a3fa6c4278e028402023-11-26T12:52:40ZengNature PortfolioScientific Reports2045-23222023-09-011311810.1038/s41598-023-40722-4Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping studyCaroline Reindl0Katrin Walther1Anna-Lena Allgäuer2Johannes D. Lang3Tamara M. Welte4Jenny Stritzelberger5Stephanie Gollwitzer6Michael Schwarz7Regina Trollmann8Dominik Madzar9Michael Knott10Arnd Doerfler11Frank Seifert12Karl Rössler13Sebastian Brandner14Stefan Rampp15Stefan Schwab16Hajo M. Hamer17Epilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenDepartment of Neuropaediatrics, University Hospital ErlangenDepartment of Neurology, University Hospital ErlangenDepartment of Neuroradiology, University Hospital ErlangenDepartment of Neuroradiology, University Hospital ErlangenDepartment of Neurology, University Hospital ErlangenDepartment of Neurosurgery, University Hospital Vienna (AKH)Department of Neurosurgery, University Hospital ErlangenDepartment of Neurosurgery, University Hospital ErlangenDepartment of Neurology, University Hospital ErlangenEpilepsy Center Department of Neurology, University Hospital ErlangenAbstract Age at onset of epilepsy is an important predictor of deterioration in naming ability following epilepsy surgery. In 141 patients with left hemispheric epilepsy and language dominance who received epilepsy surgery at the Epilepsy Centre Erlangen, naming of objects (Boston naming test, BNT) was assessed preoperatively and 6 months postoperatively. Surgical lesions were plotted on postoperative MRI and normalized for statistical analysis using voxel-based lesion-symptom mapping (VBLSM). The correlation between lesion and presence of postoperative naming deterioration was examined varying the considered age range of epilepsy onsets. The VBLSM analysis showed that volumes of cortex areas in the left temporal lobe, which were associated with postoperative decline of naming, increased with each year of later epilepsy onset. In patients with later onset, an increasing left posterior temporobasal area was significantly associated with a postoperative deficit when included in the resection. For late epilepsy onset, the temporomesial expansion also included the left hippocampus. The results underline that early onset of epilepsy is a good prognostic factor for unchanged postoperative naming ability following epilepsy surgery. For later age of epilepsy onset, the extent of the area at risk of postoperative naming deficit at 6 months after surgery included an increasing left temporobasal area which finally also comprised the hippocampus.https://doi.org/10.1038/s41598-023-40722-4 |
| spellingShingle | Caroline Reindl Katrin Walther Anna-Lena Allgäuer Johannes D. Lang Tamara M. Welte Jenny Stritzelberger Stephanie Gollwitzer Michael Schwarz Regina Trollmann Dominik Madzar Michael Knott Arnd Doerfler Frank Seifert Karl Rössler Sebastian Brandner Stefan Rampp Stefan Schwab Hajo M. Hamer Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study Scientific Reports |
| title | Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study |
| title_full | Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study |
| title_fullStr | Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study |
| title_full_unstemmed | Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study |
| title_short | Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study |
| title_sort | age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery a voxel based lesion symptom mapping study |
| url | https://doi.org/10.1038/s41598-023-40722-4 |
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