Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis
Abstract Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes mild cold-like symptoms and severe lower respiratory tract infections, causing hospitalizations in children, the elderly and immunocompromised individuals. Due to genetic variability, this virus causes life-threa...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-40760-y |
| _version_ | 1797453314057568256 |
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| author | Tushar Ahmed Shishir Otun Saha Sultana Rajia Spencer Mark Mondol Md. Habib Ullah Masum Md. Mizanur Rahaman Foysal Hossen Newaz Mohammed Bahadur Firoz Ahmed Iftekhar Bin Naser Mohammad Ruhul Amin |
| author_facet | Tushar Ahmed Shishir Otun Saha Sultana Rajia Spencer Mark Mondol Md. Habib Ullah Masum Md. Mizanur Rahaman Foysal Hossen Newaz Mohammed Bahadur Firoz Ahmed Iftekhar Bin Naser Mohammad Ruhul Amin |
| author_sort | Tushar Ahmed Shishir |
| collection | DOAJ |
| description | Abstract Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes mild cold-like symptoms and severe lower respiratory tract infections, causing hospitalizations in children, the elderly and immunocompromised individuals. Due to genetic variability, this virus causes life-threatening pneumonia and bronchiolitis in young infants. Thus, we examined 3600 whole genome sequences submitted to GISAID by 31 December 2022 to examine the genetic variability of RSV. While RSVA and RSVB coexist throughout RSV seasons, RSVA is more prevalent, fatal, and epidemic-prone in several countries, including the United States, the United Kingdom, Australia, and China. Additionally, the virus's attachment glycoprotein and fusion protein were highly mutated, with RSVA having higher Shannon entropy than RSVB. The genetic makeup of these viruses contributes significantly to their prevalence and epidemic potential. Several strain-specific SNPs co-occurred with specific haplotypes of RSVA and RSVB, followed by different haplotypes of the viruses. RSVA and RSVB have the highest linkage probability at loci T12844A/T3483C and G13959T/C2198T, respectively. The results indicate that specific haplotypes and SNPs may significantly affect their spread. Overall, this analysis presents a promising strategy for tracking the evolving epidemic situation and genetic variants of RSV, which could aid in developing effective control, prophylactic, and treatment strategies. |
| first_indexed | 2024-03-09T15:20:04Z |
| format | Article |
| id | doaj.art-f86db01b81bf4bf8904610ca51bae0d4 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:20:04Z |
| publishDate | 2023-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-f86db01b81bf4bf8904610ca51bae0d42023-11-26T12:51:55ZengNature PortfolioScientific Reports2045-23222023-08-0113111110.1038/s41598-023-40760-yGenome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysisTushar Ahmed Shishir0Otun Saha1Sultana Rajia2Spencer Mark Mondol3Md. Habib Ullah Masum4Md. Mizanur Rahaman5Foysal Hossen6Newaz Mohammed Bahadur7Firoz Ahmed8Iftekhar Bin Naser9Mohammad Ruhul Amin10Department of Mathematics and Natural Sciences, BRAC UniversityDepartment of Microbiology, Noakhali Science and Technology UniversityDepartment of Microbiology, Noakhali Science and Technology UniversityDepartment of Microbiology, University of DhakaDepartment of Microbiology, Noakhali Science and Technology UniversityDepartment of Microbiology, University of DhakaDepartment of Microbiology, Noakhali Science and Technology UniversityDepartment of Chemistry, Noakhali Science and Technology UniversityDepartment of Microbiology, Noakhali Science and Technology UniversityDepartment of Mathematics and Natural Sciences, BRAC UniversityDepartment of Microbiology, Noakhali Science and Technology UniversityAbstract Respiratory syncytial virus (RSV) is a common respiratory pathogen that causes mild cold-like symptoms and severe lower respiratory tract infections, causing hospitalizations in children, the elderly and immunocompromised individuals. Due to genetic variability, this virus causes life-threatening pneumonia and bronchiolitis in young infants. Thus, we examined 3600 whole genome sequences submitted to GISAID by 31 December 2022 to examine the genetic variability of RSV. While RSVA and RSVB coexist throughout RSV seasons, RSVA is more prevalent, fatal, and epidemic-prone in several countries, including the United States, the United Kingdom, Australia, and China. Additionally, the virus's attachment glycoprotein and fusion protein were highly mutated, with RSVA having higher Shannon entropy than RSVB. The genetic makeup of these viruses contributes significantly to their prevalence and epidemic potential. Several strain-specific SNPs co-occurred with specific haplotypes of RSVA and RSVB, followed by different haplotypes of the viruses. RSVA and RSVB have the highest linkage probability at loci T12844A/T3483C and G13959T/C2198T, respectively. The results indicate that specific haplotypes and SNPs may significantly affect their spread. Overall, this analysis presents a promising strategy for tracking the evolving epidemic situation and genetic variants of RSV, which could aid in developing effective control, prophylactic, and treatment strategies.https://doi.org/10.1038/s41598-023-40760-y |
| spellingShingle | Tushar Ahmed Shishir Otun Saha Sultana Rajia Spencer Mark Mondol Md. Habib Ullah Masum Md. Mizanur Rahaman Foysal Hossen Newaz Mohammed Bahadur Firoz Ahmed Iftekhar Bin Naser Mohammad Ruhul Amin Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis Scientific Reports |
| title | Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis |
| title_full | Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis |
| title_fullStr | Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis |
| title_full_unstemmed | Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis |
| title_short | Genome-wide study of globally distributed respiratory syncytial virus (RSV) strains implicates diversification utilizing phylodynamics and mutational analysis |
| title_sort | genome wide study of globally distributed respiratory syncytial virus rsv strains implicates diversification utilizing phylodynamics and mutational analysis |
| url | https://doi.org/10.1038/s41598-023-40760-y |
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