Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer
Background: This study was conducted to examine the hypothesis that umbilical cord blood platelet lysate (UCB-PL) gel has a significant impact on the healing rate of DFU. Μethods: In this open-labeled, randomized controlled trial, 110 patients were randomized to treatment with UCB-PL gel (UCB-PL gro...
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MDPI AG
2024-02-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/13/5/1310 |
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| author | Vaia Lambadiari Aikaterini Kountouri Fοteini Psahoulia Georgia-Angeliki Koliou Andreas Lazaris Efstathios Michalopoulos Panagiotis Mallis Emmanouil Korakas Ioanna Eleftheriadou Konstantinos Balampanis Markos Sarris Panagiotis Tsirigotis George Geroulakos Catherine Stavropoulos-Giokas George D. Dimitriadis Nikolaos Tentolouris |
| author_facet | Vaia Lambadiari Aikaterini Kountouri Fοteini Psahoulia Georgia-Angeliki Koliou Andreas Lazaris Efstathios Michalopoulos Panagiotis Mallis Emmanouil Korakas Ioanna Eleftheriadou Konstantinos Balampanis Markos Sarris Panagiotis Tsirigotis George Geroulakos Catherine Stavropoulos-Giokas George D. Dimitriadis Nikolaos Tentolouris |
| author_sort | Vaia Lambadiari |
| collection | DOAJ |
| description | Background: This study was conducted to examine the hypothesis that umbilical cord blood platelet lysate (UCB-PL) gel has a significant impact on the healing rate of DFU. Μethods: In this open-labeled, randomized controlled trial, 110 patients were randomized to treatment with UCB-PL gel (UCB-PL group, n = 52) every three days for one month or dressing with normal saline (control group, n = 58). All participants were followed up for 20 weeks post treatment. Ulcer surface area was assessed with the imitoMeasure application at two, four, and six weeks, and two, four and six months. This study’s main outcome was the reduction in ulcer size over the six-month study period. Results: The mean ulcer area at baseline was 4.1 cm<sup>2</sup> in the UCB-PL group and 1.7 cm<sup>2</sup> in the control group. At six months post treatment, patients on the UCB-PL treatment displayed a significant reduction in ulcer size compared to baseline 0.12 (0–8.16) in contrast to a more modest change in the control group 1.05 (0–24.7). The ulcer area was decreased at the end of the study in 40 patients (97.6%) in the UCB-PL group and 27 (73%) in the control group (Fisher’s <i>p</i> = 0.002). Conclusions: The application of UCB-PL gel in DFU resulted in a significant reduction in ulcer size compared to regular saline dressing. |
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| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-04-25T00:27:16Z |
| publishDate | 2024-02-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-f86ee533c2ab4b24890b33b71fcf5b3e2024-03-12T16:47:57ZengMDPI AGJournal of Clinical Medicine2077-03832024-02-01135131010.3390/jcm13051310Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot UlcerVaia Lambadiari0Aikaterini Kountouri1Fοteini Psahoulia2Georgia-Angeliki Koliou3Andreas Lazaris4Efstathios Michalopoulos5Panagiotis Mallis6Emmanouil Korakas7Ioanna Eleftheriadou8Konstantinos Balampanis9Markos Sarris10Panagiotis Tsirigotis11George Geroulakos12Catherine Stavropoulos-Giokas13George D. Dimitriadis14Nikolaos Tentolouris15Second Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Vascular Surgery, Attikon University Hospital, 12462 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Vascular Surgery, Attikon University Hospital, 12462 Athens, GreeceHellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 11527 Athens, GreeceHellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 11527 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceFirst Department of Propaedeutic Internal Medicine, Diabetes Centre, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceHealth and Social Care Management, University of West Attica, 12241 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Vascular Surgery, Attikon University Hospital, 12462 Athens, GreeceHellenic Cord Blood Bank, Biomedical Research Foundation Academy of Athens, 11527 Athens, GreeceSector of Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Propaedeutic Internal Medicine, Diabetes Centre, Laiko General Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceBackground: This study was conducted to examine the hypothesis that umbilical cord blood platelet lysate (UCB-PL) gel has a significant impact on the healing rate of DFU. Μethods: In this open-labeled, randomized controlled trial, 110 patients were randomized to treatment with UCB-PL gel (UCB-PL group, n = 52) every three days for one month or dressing with normal saline (control group, n = 58). All participants were followed up for 20 weeks post treatment. Ulcer surface area was assessed with the imitoMeasure application at two, four, and six weeks, and two, four and six months. This study’s main outcome was the reduction in ulcer size over the six-month study period. Results: The mean ulcer area at baseline was 4.1 cm<sup>2</sup> in the UCB-PL group and 1.7 cm<sup>2</sup> in the control group. At six months post treatment, patients on the UCB-PL treatment displayed a significant reduction in ulcer size compared to baseline 0.12 (0–8.16) in contrast to a more modest change in the control group 1.05 (0–24.7). The ulcer area was decreased at the end of the study in 40 patients (97.6%) in the UCB-PL group and 27 (73%) in the control group (Fisher’s <i>p</i> = 0.002). Conclusions: The application of UCB-PL gel in DFU resulted in a significant reduction in ulcer size compared to regular saline dressing.https://www.mdpi.com/2077-0383/13/5/1310diabetic footdiabetic foot treatmentplatelet rich plasmaumbilical cord bloodplatelet lysate |
| spellingShingle | Vaia Lambadiari Aikaterini Kountouri Fοteini Psahoulia Georgia-Angeliki Koliou Andreas Lazaris Efstathios Michalopoulos Panagiotis Mallis Emmanouil Korakas Ioanna Eleftheriadou Konstantinos Balampanis Markos Sarris Panagiotis Tsirigotis George Geroulakos Catherine Stavropoulos-Giokas George D. Dimitriadis Nikolaos Tentolouris Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer Journal of Clinical Medicine diabetic foot diabetic foot treatment platelet rich plasma umbilical cord blood platelet lysate |
| title | Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer |
| title_full | Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer |
| title_fullStr | Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer |
| title_full_unstemmed | Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer |
| title_short | Treatment with Umbilical Cord Blood Platelet Lysate Gel Improves Healing of Diabetic Foot Ulcer |
| title_sort | treatment with umbilical cord blood platelet lysate gel improves healing of diabetic foot ulcer |
| topic | diabetic foot diabetic foot treatment platelet rich plasma umbilical cord blood platelet lysate |
| url | https://www.mdpi.com/2077-0383/13/5/1310 |
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