Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise
The application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this technique to diagnostic nuclear medicine outside...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Diagnostics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2075-4418/11/12/2333 |
| _version_ | 1797505502768267264 |
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| author | Stijn De Schepper Gopinath Gnanasegaran John C. Dickson Tim Van den Wyngaert |
| author_facet | Stijn De Schepper Gopinath Gnanasegaran John C. Dickson Tim Van den Wyngaert |
| author_sort | Stijn De Schepper |
| collection | DOAJ |
| description | The application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this technique to diagnostic nuclear medicine outside this setting is rather slow. Clinical research has, in some examples, already shown an association between imaging metrics and clinical diagnosis, but the applications, in general, lack proper validation because of the absence of a ground truth measurement. Meanwhile, additive manufacturing or 3D printing has seen rapid improvements, increasing its uptake in medical imaging. Three-dimensional printed phantoms have already made a significant impact on quantitative imaging, a trend that is likely to increase in the future. In this review, we summarize the data of recent literature to underpin our premise that the validation of diagnostic applications in nuclear medicine using application-specific phantoms is within reach given the current state-of-the-art in additive manufacturing or 3D printing. |
| first_indexed | 2024-03-10T04:19:30Z |
| format | Article |
| id | doaj.art-f87188f94b2a4d198bd9e1c95afbc433 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T04:19:30Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-f87188f94b2a4d198bd9e1c95afbc4332023-11-23T07:54:37ZengMDPI AGDiagnostics2075-44182021-12-011112233310.3390/diagnostics11122333Absolute Quantification in Diagnostic SPECT/CT: The Phantom PremiseStijn De Schepper0Gopinath Gnanasegaran1John C. Dickson2Tim Van den Wyngaert3Department of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, BelgiumDepartment of Nuclear Medicine, Royal Free London NHS, London NW3 2QG, UKInstitute of Nuclear Medicine, University College of London Hospitals NHS, London NW1 2BU, UKDepartment of Nuclear Medicine, Antwerp University Hospital, 2650 Edegem, BelgiumThe application of absolute quantification in SPECT/CT has seen increased interest in the context of radionuclide therapies where patient-specific dosimetry is a requirement within the European Union (EU) legislation. However, the translation of this technique to diagnostic nuclear medicine outside this setting is rather slow. Clinical research has, in some examples, already shown an association between imaging metrics and clinical diagnosis, but the applications, in general, lack proper validation because of the absence of a ground truth measurement. Meanwhile, additive manufacturing or 3D printing has seen rapid improvements, increasing its uptake in medical imaging. Three-dimensional printed phantoms have already made a significant impact on quantitative imaging, a trend that is likely to increase in the future. In this review, we summarize the data of recent literature to underpin our premise that the validation of diagnostic applications in nuclear medicine using application-specific phantoms is within reach given the current state-of-the-art in additive manufacturing or 3D printing.https://www.mdpi.com/2075-4418/11/12/2333absolute quantificationSPECT/CTphantomsdiagnostics3D printing |
| spellingShingle | Stijn De Schepper Gopinath Gnanasegaran John C. Dickson Tim Van den Wyngaert Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise Diagnostics absolute quantification SPECT/CT phantoms diagnostics 3D printing |
| title | Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise |
| title_full | Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise |
| title_fullStr | Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise |
| title_full_unstemmed | Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise |
| title_short | Absolute Quantification in Diagnostic SPECT/CT: The Phantom Premise |
| title_sort | absolute quantification in diagnostic spect ct the phantom premise |
| topic | absolute quantification SPECT/CT phantoms diagnostics 3D printing |
| url | https://www.mdpi.com/2075-4418/11/12/2333 |
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