Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus
AIM: This study was aimed at investigation of daily glycemic variations in children and adolescents with type 1 diabetes mellitus (T1DM) on continuous subcutaneous insulin infusion (CSII) in order to define in greater detail the correlation of said parameters with periods of age to...
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| Format: | Article |
| Language: | English |
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Endocrinology Research Centre
2013-09-01
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| Series: | Сахарный диабет |
| Subjects: | |
| Online Access: | https://www.dia-endojournals.ru/jour/article/view/98 |
| _version_ | 1797255250350964736 |
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| author | Dmitriy Nikitich Laptev Yury Ivanovich Filippov Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva |
| author_facet | Dmitriy Nikitich Laptev Yury Ivanovich Filippov Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva |
| author_sort | Dmitriy Nikitich Laptev |
| collection | DOAJ |
| description | AIM: This study was aimed at investigation of daily glycemic variations in children and adolescents with type 1 diabetes mellitus (T1DM) on continuous subcutaneous insulin infusion (CSII) in order to define in greater detail the correlation of said parameters with periods of age to the end of improving current recommendations for pump settings adjustment. MATERIALS AND METHODS: 138 children and adolescents aged 1?18 years on CSII therapy took part in this study. Patients were subdivided into three groups according to their age: preschool children (n=23), prepubertal children aged <12 years (n=39) and teenagers up to 18 years old (n=76). CSII regimens were analyzed in every group, including average daily insulin dose, basal-to-bolus ratio, daily basal profiles, carbohydrate ratio (CR) and insulin sensitivity factor (ISF). RESULTS: Daily requirement for both basal and bolus insulin does differ between ages. Youngest children require higher basal infusion rate during evening hours and first half of the nighttime while demonstrating least requirement at daytime. Instead, prepubertal children and adolescents require higher basal infusion rate during early morning hours. We also show CR and ISF to be dependent of daytime in all studied age grades. CONCLUSIONS: Basal-to-bolus ratio along with circadian variability in requirement for insulin are clearly governed by patient's age. Importantly, the ratios for bolus calculations, developed from our data, significantly differ from those provided by popular formulas, suggesting the latter be modified into taking regard of the age grade for proper individual adjustment of pump settings. |
| first_indexed | 2024-03-08T15:21:55Z |
| format | Article |
| id | doaj.art-f8721f0197ec4fe084491e9f06fffe45 |
| institution | Directory Open Access Journal |
| issn | 2072-0351 2072-0378 |
| language | English |
| last_indexed | 2024-04-24T22:02:52Z |
| publishDate | 2013-09-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Сахарный диабет |
| spelling | doaj.art-f8721f0197ec4fe084491e9f06fffe452024-03-20T11:47:58ZengEndocrinology Research CentreСахарный диабет2072-03512072-03782013-09-0116310911510.14341/2072-0351-9882Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitusDmitriy Nikitich Laptev0Yury Ivanovich Filippov1Andrey Olegovich Emel'yanov2Tamara Leonidovna Kuraeva3Endocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowEndocrinology Research Centre, MoscowAIM: This study was aimed at investigation of daily glycemic variations in children and adolescents with type 1 diabetes mellitus (T1DM) on continuous subcutaneous insulin infusion (CSII) in order to define in greater detail the correlation of said parameters with periods of age to the end of improving current recommendations for pump settings adjustment. MATERIALS AND METHODS: 138 children and adolescents aged 1?18 years on CSII therapy took part in this study. Patients were subdivided into three groups according to their age: preschool children (n=23), prepubertal children aged <12 years (n=39) and teenagers up to 18 years old (n=76). CSII regimens were analyzed in every group, including average daily insulin dose, basal-to-bolus ratio, daily basal profiles, carbohydrate ratio (CR) and insulin sensitivity factor (ISF). RESULTS: Daily requirement for both basal and bolus insulin does differ between ages. Youngest children require higher basal infusion rate during evening hours and first half of the nighttime while demonstrating least requirement at daytime. Instead, prepubertal children and adolescents require higher basal infusion rate during early morning hours. We also show CR and ISF to be dependent of daytime in all studied age grades. CONCLUSIONS: Basal-to-bolus ratio along with circadian variability in requirement for insulin are clearly governed by patient's age. Importantly, the ratios for bolus calculations, developed from our data, significantly differ from those provided by popular formulas, suggesting the latter be modified into taking regard of the age grade for proper individual adjustment of pump settings.https://www.dia-endojournals.ru/jour/article/view/98diabetes mellitusinsulin pump therapycsiibolus wizardcarbohydrate ratioinsulin sensitivity factorbasal profile |
| spellingShingle | Dmitriy Nikitich Laptev Yury Ivanovich Filippov Andrey Olegovich Emel'yanov Tamara Leonidovna Kuraeva Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus Сахарный диабет diabetes mellitus insulin pump therapy csii bolus wizard carbohydrate ratio insulin sensitivity factor basal profile |
| title | Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus |
| title_full | Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus |
| title_fullStr | Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus |
| title_full_unstemmed | Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus |
| title_short | Age-adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus |
| title_sort | age adjustment of insulin pump settings in children and adolescents with type 1 diabetes mellitus |
| topic | diabetes mellitus insulin pump therapy csii bolus wizard carbohydrate ratio insulin sensitivity factor basal profile |
| url | https://www.dia-endojournals.ru/jour/article/view/98 |
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