Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis.
BACKGROUND: Periventricular Leukomalacia (PVL) affects white matter, but grey matter injuries have also been reported, particularly in the dorsomedial nucleus and the cortex. Both structures have been related to working memory (WM) processes. The aim of this study was to compare behavioral performan...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3724899?pdf=render |
| _version_ | 1818583773673947136 |
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| author | María Luisa García-Gomar Efraín Santiago-Rodríguez Mario Rodríguez-Camacho Thalía Harmony |
| author_facet | María Luisa García-Gomar Efraín Santiago-Rodríguez Mario Rodríguez-Camacho Thalía Harmony |
| author_sort | María Luisa García-Gomar |
| collection | DOAJ |
| description | BACKGROUND: Periventricular Leukomalacia (PVL) affects white matter, but grey matter injuries have also been reported, particularly in the dorsomedial nucleus and the cortex. Both structures have been related to working memory (WM) processes. The aim of this study was to compare behavioral performances and EEG power spectra during a visuospatial working memory task (VSWMT) of toddlers with a history of PVL and healthy toddlers. METHODOLOGY/PRINCIPAL FINDINGS: A prospective, comparative study of WM was conducted in toddlers with a history of PVL and healthy toddlers. The task responses and the EEG narrow-band power spectra during a VSWMT were compared in both groups. The EEG absolute power was analyzed during the following three conditions: baseline, attention and WM retention. The number of correct responses was higher in the healthy group (20.5 ± 5.0) compared to the PVL group (16.1 ± 3.9) (p = 0.04). The healthy group had absolute power EEG increases (p ≤ 0.05) during WM compared to the attention condition in the bilateral frontal and right temporal, parietal and occipital regions in frequencies ranging from 1.17 to 2.34 Hz and in the right temporal, parietal and occipital regions in frequencies ranging from 14.06 to 15.23 Hz. In contrast, the PVL group had absolute power increases (p ≤ 0.05) in the bilateral fronto-parietal, left central and occipital regions in frequencies that ranged from 1.17 to 3.52 Hz and in the bilateral frontal and right temporal regions in frequencies ranging from 9.37 to 19.14 Hz. CONCLUSIONS/SIGNIFICANCE: This study provides evidence that PVL toddlers have visuospatial WM deficits and a very different pattern of absolute power increases compared to a healthy group of toddlers, with greater absolute power in the low frequency range and widespread neuronal networks in the WM retention phase. |
| first_indexed | 2024-12-16T08:10:37Z |
| format | Article |
| id | doaj.art-f8740c45cfc74a2c8fda100c303e834b |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:10:37Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f8740c45cfc74a2c8fda100c303e834b2022-12-21T22:38:21ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0187e6983710.1371/journal.pone.0069837Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis.María Luisa García-GomarEfraín Santiago-RodríguezMario Rodríguez-CamachoThalía HarmonyBACKGROUND: Periventricular Leukomalacia (PVL) affects white matter, but grey matter injuries have also been reported, particularly in the dorsomedial nucleus and the cortex. Both structures have been related to working memory (WM) processes. The aim of this study was to compare behavioral performances and EEG power spectra during a visuospatial working memory task (VSWMT) of toddlers with a history of PVL and healthy toddlers. METHODOLOGY/PRINCIPAL FINDINGS: A prospective, comparative study of WM was conducted in toddlers with a history of PVL and healthy toddlers. The task responses and the EEG narrow-band power spectra during a VSWMT were compared in both groups. The EEG absolute power was analyzed during the following three conditions: baseline, attention and WM retention. The number of correct responses was higher in the healthy group (20.5 ± 5.0) compared to the PVL group (16.1 ± 3.9) (p = 0.04). The healthy group had absolute power EEG increases (p ≤ 0.05) during WM compared to the attention condition in the bilateral frontal and right temporal, parietal and occipital regions in frequencies ranging from 1.17 to 2.34 Hz and in the right temporal, parietal and occipital regions in frequencies ranging from 14.06 to 15.23 Hz. In contrast, the PVL group had absolute power increases (p ≤ 0.05) in the bilateral fronto-parietal, left central and occipital regions in frequencies that ranged from 1.17 to 3.52 Hz and in the bilateral frontal and right temporal regions in frequencies ranging from 9.37 to 19.14 Hz. CONCLUSIONS/SIGNIFICANCE: This study provides evidence that PVL toddlers have visuospatial WM deficits and a very different pattern of absolute power increases compared to a healthy group of toddlers, with greater absolute power in the low frequency range and widespread neuronal networks in the WM retention phase.http://europepmc.org/articles/PMC3724899?pdf=render |
| spellingShingle | María Luisa García-Gomar Efraín Santiago-Rodríguez Mario Rodríguez-Camacho Thalía Harmony Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. PLoS ONE |
| title | Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. |
| title_full | Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. |
| title_fullStr | Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. |
| title_full_unstemmed | Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. |
| title_short | Visuospatial working memory in toddlers with a history of periventricular Leukomalacia: an EEG narrow-band power analysis. |
| title_sort | visuospatial working memory in toddlers with a history of periventricular leukomalacia an eeg narrow band power analysis |
| url | http://europepmc.org/articles/PMC3724899?pdf=render |
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