Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.
Bibliographic Details
| Main Authors: |
Kotaro Kiga,
Xin-Ee Tan,
Rodrigo Ibarra-Chávez,
Shinya Watanabe,
Yoshifumi Aiba,
Yusuke Sato’o,
Feng-Yu Li,
Teppei Sasahara,
Bintao Cui,
Moriyuki Kawauchi,
Tanit Boonsiri,
Kanate Thitiananpakorn,
Yusuke Taki,
Aa Haeruman Azam,
Masato Suzuki,
José R. Penadés,
Longzhu Cui |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-16731-6
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