Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria
CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16731-6 |
| _version_ | 1819129370951811072 |
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| author | Kotaro Kiga Xin-Ee Tan Rodrigo Ibarra-Chávez Shinya Watanabe Yoshifumi Aiba Yusuke Sato’o Feng-Yu Li Teppei Sasahara Bintao Cui Moriyuki Kawauchi Tanit Boonsiri Kanate Thitiananpakorn Yusuke Taki Aa Haeruman Azam Masato Suzuki José R. Penadés Longzhu Cui |
| author_facet | Kotaro Kiga Xin-Ee Tan Rodrigo Ibarra-Chávez Shinya Watanabe Yoshifumi Aiba Yusuke Sato’o Feng-Yu Li Teppei Sasahara Bintao Cui Moriyuki Kawauchi Tanit Boonsiri Kanate Thitiananpakorn Yusuke Taki Aa Haeruman Azam Masato Suzuki José R. Penadés Longzhu Cui |
| author_sort | Kotaro Kiga |
| collection | DOAJ |
| description | CRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes. |
| first_indexed | 2024-12-22T08:42:39Z |
| format | Article |
| id | doaj.art-f87529d3a0c642c78aab97a22b66d12b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:42:39Z |
| publishDate | 2020-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f87529d3a0c642c78aab97a22b66d12b2022-12-21T18:32:11ZengNature PortfolioNature Communications2041-17232020-06-0111111110.1038/s41467-020-16731-6Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteriaKotaro Kiga0Xin-Ee Tan1Rodrigo Ibarra-Chávez2Shinya Watanabe3Yoshifumi Aiba4Yusuke Sato’o5Feng-Yu Li6Teppei Sasahara7Bintao Cui8Moriyuki Kawauchi9Tanit Boonsiri10Kanate Thitiananpakorn11Yusuke Taki12Aa Haeruman Azam13Masato Suzuki14José R. Penadés15Longzhu Cui16Division of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityInstitute of Infection, Immunity & Inflammation, University of GlasgowDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityAntimicrobial Resistance Research Center, National Institute of Infectious DiseasesInstitute of Infection, Immunity & Inflammation, University of GlasgowDivision of Bacteriology, Department of Infection and Immunity, School of Medicine, Jichi Medical UniversityCRISPR technology is emerging as a potential antimicrobial against antimicrobial-resistant bacteria. Here the authors develop a bacteriophage delivered Cas13a system for killing target bacteria and detecting bacterial genes.https://doi.org/10.1038/s41467-020-16731-6 |
| spellingShingle | Kotaro Kiga Xin-Ee Tan Rodrigo Ibarra-Chávez Shinya Watanabe Yoshifumi Aiba Yusuke Sato’o Feng-Yu Li Teppei Sasahara Bintao Cui Moriyuki Kawauchi Tanit Boonsiri Kanate Thitiananpakorn Yusuke Taki Aa Haeruman Azam Masato Suzuki José R. Penadés Longzhu Cui Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria Nature Communications |
| title | Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria |
| title_full | Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria |
| title_fullStr | Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria |
| title_full_unstemmed | Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria |
| title_short | Development of CRISPR-Cas13a-based antimicrobials capable of sequence-specific killing of target bacteria |
| title_sort | development of crispr cas13a based antimicrobials capable of sequence specific killing of target bacteria |
| url | https://doi.org/10.1038/s41467-020-16731-6 |
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