Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16
Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, P...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2016-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11533 |
| _version_ | 1818342595374350336 |
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| author | Hanying Ding Shasha Zheng Daniel Garcia-Ruiz Dongxia Hou Zhe Wei Zhicong Liao Limin Li Yujing Zhang Xiao Han Ke Zen Chen-Yu Zhang Jing Li Xiaohong Jiang |
| author_facet | Hanying Ding Shasha Zheng Daniel Garcia-Ruiz Dongxia Hou Zhe Wei Zhicong Liao Limin Li Yujing Zhang Xiao Han Ke Zen Chen-Yu Zhang Jing Li Xiaohong Jiang |
| author_sort | Hanying Ding |
| collection | DOAJ |
| description | Visceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, PRDM16. |
| first_indexed | 2024-12-13T16:17:11Z |
| format | Article |
| id | doaj.art-f877f6cf92a7471b819414666df8c0fe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:17:11Z |
| publishDate | 2016-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f877f6cf92a7471b819414666df8c0fe2022-12-21T23:38:49ZengNature PortfolioNature Communications2041-17232016-05-017111710.1038/ncomms11533Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16Hanying Ding0Shasha Zheng1Daniel Garcia-Ruiz2Dongxia Hou3Zhe Wei4Zhicong Liao5Limin Li6Yujing Zhang7Xiao Han8Ke Zen9Chen-Yu Zhang10Jing Li11Xiaohong Jiang12State Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityKey Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityState Key Laboratory of Pharmaceutical Biotechnology, Collaborative Innovation Center of Chemistry for Life Sciences, Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of life sciences, Nanjing UniversityVisceral adiposity is associated with metabolic diseases, whereas subcutaneous adiposity is comparatively benign. Here, the authors report that subcutaneous adipose tissue adopts visceral-like characteristics in response to prolonged fasting, and show this is mediated by miR-149-3p and its target, PRDM16.https://doi.org/10.1038/ncomms11533 |
| spellingShingle | Hanying Ding Shasha Zheng Daniel Garcia-Ruiz Dongxia Hou Zhe Wei Zhicong Liao Limin Li Yujing Zhang Xiao Han Ke Zen Chen-Yu Zhang Jing Li Xiaohong Jiang Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 Nature Communications |
| title | Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 |
| title_full | Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 |
| title_fullStr | Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 |
| title_full_unstemmed | Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 |
| title_short | Fasting induces a subcutaneous-to-visceral fat switch mediated by microRNA-149-3p and suppression of PRDM16 |
| title_sort | fasting induces a subcutaneous to visceral fat switch mediated by microrna 149 3p and suppression of prdm16 |
| url | https://doi.org/10.1038/ncomms11533 |
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