Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial
Objective: The objective of this study was to assess the effectiveness of triamcinolone in combination with pentoxifylline and vitamin E in the treatment of patients with level two and three oral submucous fibrosis. Methods: The study aimed to compare the efficacy of corticosteroid injections (triam...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-09-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121231200757 |
| _version_ | 1797670825505062912 |
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| author | Saeed Ullah Shah Seeme Nigar Rahima Yousofi Afsheen Maqsood Sara Altamash Abhishek lal Zarak Khan Naseer Ahmed Artak Heboyan |
| author_facet | Saeed Ullah Shah Seeme Nigar Rahima Yousofi Afsheen Maqsood Sara Altamash Abhishek lal Zarak Khan Naseer Ahmed Artak Heboyan |
| author_sort | Saeed Ullah Shah |
| collection | DOAJ |
| description | Objective: The objective of this study was to assess the effectiveness of triamcinolone in combination with pentoxifylline and vitamin E in the treatment of patients with level two and three oral submucous fibrosis. Methods: The study aimed to compare the efficacy of corticosteroid injections (triamcinolone) versus pentoxifylline and vitamin E in the therapy of patients with stage two and three oral submucous fibrosis. A total of 42 participants with indications and features of oral submucous fibrosis were enrolled between January 2020 and September 2021. The patients’ age and mouth opening were evaluated, and descriptive statistics and paired t -test were used for analytical investigation. Results: The study showed a statistically significant improvement in both treatment groups ( p = 0.001) concerning pre- and post-treatment deviations. However, when comparing the standard differences in treatment outcomes between the two study groups, only mouth opening exhibited a statistically significant difference ( p = 0.001). Conclusions: The findings indicate that a treatment regimen combining pentoxifylline and triamcinolone can significantly alleviate oral submucous fibrosis symptoms, including mouth opening, pain, and flaring agitation, thereby enhancing the affected individual’s quality of life. |
| first_indexed | 2024-03-11T21:06:27Z |
| format | Article |
| id | doaj.art-f878260ca0fc48df9f6573acf019f57a |
| institution | Directory Open Access Journal |
| issn | 2050-3121 |
| language | English |
| last_indexed | 2024-03-11T21:06:27Z |
| publishDate | 2023-09-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj.art-f878260ca0fc48df9f6573acf019f57a2023-09-29T13:04:11ZengSAGE PublishingSAGE Open Medicine2050-31212023-09-011110.1177/20503121231200757Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trialSaeed Ullah Shah0Seeme Nigar1Rahima Yousofi2Afsheen Maqsood3Sara Altamash4Abhishek lal5Zarak Khan6Naseer Ahmed7Artak Heboyan8Department of Oral Medicine, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Oral Pathology, Altamash Institute of Dental Medicine, Karachi, PakistanResearch Department and Review Cell, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Oral Pathology, Bahria University Dental College, Karachi, PakistanDepartment of Orthodontics, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Prosthodontics, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Prosthodontics, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Prosthodontics, Altamash Institute of Dental Medicine, Karachi, PakistanDepartment of Prosthodontics, Faculty of Stomatology, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, ArmeniaObjective: The objective of this study was to assess the effectiveness of triamcinolone in combination with pentoxifylline and vitamin E in the treatment of patients with level two and three oral submucous fibrosis. Methods: The study aimed to compare the efficacy of corticosteroid injections (triamcinolone) versus pentoxifylline and vitamin E in the therapy of patients with stage two and three oral submucous fibrosis. A total of 42 participants with indications and features of oral submucous fibrosis were enrolled between January 2020 and September 2021. The patients’ age and mouth opening were evaluated, and descriptive statistics and paired t -test were used for analytical investigation. Results: The study showed a statistically significant improvement in both treatment groups ( p = 0.001) concerning pre- and post-treatment deviations. However, when comparing the standard differences in treatment outcomes between the two study groups, only mouth opening exhibited a statistically significant difference ( p = 0.001). Conclusions: The findings indicate that a treatment regimen combining pentoxifylline and triamcinolone can significantly alleviate oral submucous fibrosis symptoms, including mouth opening, pain, and flaring agitation, thereby enhancing the affected individual’s quality of life.https://doi.org/10.1177/20503121231200757 |
| spellingShingle | Saeed Ullah Shah Seeme Nigar Rahima Yousofi Afsheen Maqsood Sara Altamash Abhishek lal Zarak Khan Naseer Ahmed Artak Heboyan Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial SAGE Open Medicine |
| title | Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial |
| title_full | Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial |
| title_fullStr | Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial |
| title_full_unstemmed | Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial |
| title_short | Comparison of triamcinolone with pentoxifylline and vitamin E efficacy in the treatment of stage 2 and 3 oral submucous fibrosis: A randomized clinical trial |
| title_sort | comparison of triamcinolone with pentoxifylline and vitamin e efficacy in the treatment of stage 2 and 3 oral submucous fibrosis a randomized clinical trial |
| url | https://doi.org/10.1177/20503121231200757 |
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