ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells

ATP Release from Chemotherapy-Treated Dying Leukemia Cells Elicits an Immune Suppressive Effect by Increasing Regulatory T Cells and Tolerogenic Dendritic Cells

Chemotherapy-induced immunogenic cell death can favor dendritic cell (DC) cross-priming of tumor-associated antigens for T cell activation thanks to the release of damage-associated molecular patterns, including ATP. Here, we tested the hypothesis that in acute myeloid leukemia (AML), ATP release, a...

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Bibliographic Details
Main Authors: Mariangela Lecciso, Darina Ocadlikova, Sabina Sangaletti, Sara Trabanelli, Elena De Marchi, Elisa Orioli, Anna Pegoraro, Paola Portararo, Camilla Jandus, Andrea Bontadini, Annarita Redavid, Valentina Salvestrini, Pedro Romero, Mario P. Colombo, Francesco Di Virgilio, Michele Cavo, Elena Adinolfi, Antonio Curti
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
chemotherapy
ATP
dendritic cell
T regulatory cells
immunosuppression
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01918/full

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