Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis
The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations “chronic trauma and oral squam...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina
2021-12-01
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| Series: | Biomolecules & Biomedicine |
| Subjects: | |
| Online Access: | https://www.bjbms.org/ojs/index.php/bjbms/article/view/5577 |
| _version_ | 1797261339550285824 |
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| author | Archana A. Gupta Supriya Kheur Saranya Varadarajan Sameena Parveen Harisha Dewan Yaser Ali Alhazmi Thirumal A. Raj Luca Testarelli Shankargouda Patil |
| author_facet | Archana A. Gupta Supriya Kheur Saranya Varadarajan Sameena Parveen Harisha Dewan Yaser Ali Alhazmi Thirumal A. Raj Luca Testarelli Shankargouda Patil |
| author_sort | Archana A. Gupta |
| collection | DOAJ |
| description |
The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations “chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer.” Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded from the study. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for OSCC. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-OSCC. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p < 0.00001) between the chronic oral mucosal irritation and OSCC with an overall risk ratio of 2.56 at a confidence interval of 1.96-3.35. Chronic oral mucosa irritation has a significant association with OSCC, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor.
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| first_indexed | 2024-04-24T23:39:39Z |
| format | Article |
| id | doaj.art-f87bd070ec764d6784a0152b65278709 |
| institution | Directory Open Access Journal |
| issn | 2831-0896 2831-090X |
| language | English |
| last_indexed | 2024-04-24T23:39:39Z |
| publishDate | 2021-12-01 |
| publisher | Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina |
| record_format | Article |
| series | Biomolecules & Biomedicine |
| spelling | doaj.art-f87bd070ec764d6784a0152b652787092024-03-15T13:44:03ZengAssociation of Basic Medical Sciences of Federation of Bosnia and HerzegovinaBiomolecules & Biomedicine2831-08962831-090X2021-12-0121610.17305/bjbms.2021.5577Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysisArchana A. Gupta0https://orcid.org/0000-0002-5050-4288Supriya Kheur1https://orcid.org/0000-0002-2440-3547Saranya Varadarajan2https://orcid.org/0000-0002-7051-1143Sameena Parveen3https://orcid.org/0000-0002-0800-4511Harisha Dewan4https://orcid.org/0000-0002-2294-4710Yaser Ali Alhazmi5Thirumal A. Raj 6https://orcid.org/0000-0002-1079-1024Luca Testarelli7https://orcid.org/0000-0003-3904-3000Shankargouda Patil8https://orcid.org/0000-0001-7246-5497Department of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, IndiaDepartment of Oral Pathology and Microbiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pune, IndiaDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, IndiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, Jazan University, Jazan, Saudi ArabiaDepartment of Prosthetic Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi ArabiaDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi ArabiaDepartment of Oral Pathology and Microbiology, Sri Venkateswara Dental College and Hospital, Chennai, IndiaDepartment of Oral and Maxillofacial Sciences, Sapienza University, University of Rome, Rome, ItalyDepartment of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Saudi Arabia The objective of the present article was to qualitatively and quantitatively review the association between chronic mechanical irritation and oral squamous cell carcinoma (OSCC). PubMed, SCOPUS, and Web of Science databases were searched using the keyword combinations “chronic trauma and oral squamous cell carcinoma; chronic irritation and oral squamous cell carcinoma; chronic irritation and oral cancer; and chronic trauma and oral cancer.” Duplicates and irrelevant articles were excluded after the title and abstract screening. The full texts of the remaining articles were assessed using selection criteria. A total of 375 (PubMed-126; SCOPUS-152; WOS-97) articles were screened, and 343 duplicates and irrelevant articles were excluded from the study. Only 9 of the remaining 32 articles met the selection criteria and were included in the qualitative analysis. Buccal mucosa and tongue, being highly prone to chronic irritation through the dental prosthesis, were the common sites for OSCC. Edentulous subjects with ill-fitting dentures were at a high risk of developing chronic irritation associated-OSCC. According to the Joanna Briggs Institute of risk assessment, eight of the nine included studies had a low risk of bias. The quantitative analysis showed a significant association (p < 0.00001) between the chronic oral mucosal irritation and OSCC with an overall risk ratio of 2.56 at a confidence interval of 1.96-3.35. Chronic oral mucosa irritation has a significant association with OSCC, and the nature of association could be that of a potential co-factor (dependent risk factor) rather than an independent risk factor. https://www.bjbms.org/ojs/index.php/bjbms/article/view/5577Chronic traumacarcinogenesisoral squamous cell carcinomarisk factor |
| spellingShingle | Archana A. Gupta Supriya Kheur Saranya Varadarajan Sameena Parveen Harisha Dewan Yaser Ali Alhazmi Thirumal A. Raj Luca Testarelli Shankargouda Patil Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis Biomolecules & Biomedicine Chronic trauma carcinogenesis oral squamous cell carcinoma risk factor |
| title | Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis |
| title_full | Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis |
| title_fullStr | Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis |
| title_full_unstemmed | Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis |
| title_short | Chronic mechanical irritation and oral squamous cell carcinoma: A systematic review and meta-analysis |
| title_sort | chronic mechanical irritation and oral squamous cell carcinoma a systematic review and meta analysis |
| topic | Chronic trauma carcinogenesis oral squamous cell carcinoma risk factor |
| url | https://www.bjbms.org/ojs/index.php/bjbms/article/view/5577 |
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